InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dusp14

Summary

InnateDB Protein

IDBP-619958.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dusp14

Protein Name

dual specificity phosphatase 14

Synonyms

1110014C10Rik; 2310042C07Rik; D11Ertd395e; MKP-L; Mkp6;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000130624

InnateDB Gene

IDBG-205913 (Dusp14)

Protein Structure

UniProt Annotation

Function

Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0016791	phosphatase activity
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity

Biological Process

GO:0000188	inactivation of MAPK activity
GO:0006470	protein dephosphorylation
GO:0016311	dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1927168

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000340 Dual specificity phosphatase, catalytic domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR020417 Atypical dual specificity phosphatase
IPR020420 Atypical dual specificity phosphatase, subfamily B
IPR020422 Dual specificity phosphatase, subgroup, catalytic domain
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102
PF00782

PRINTS

PR00700
PR01908
PR01910

PIRSF

SMART

SM00194
SM00195

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt