Version 5.4
Mus musculus Gene: Tada2a
Summary
InnateDB Gene IDBG-205939.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tada2a
Gene Name transcriptional adaptor 2A
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000018651
Encoded Proteins
IDBP-205941
transcriptional adaptor 2A
IDBP-539226
transcriptional adaptor 2A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog null:
Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Several alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:84078920-84129600
Strand Reverse strand
Band C
Transcripts
ENSMUST00000018795 ENSMUSP00000018795
ENSMUST00000156151
ENSMUST00000141852 ENSMUSP00000119022
ENSMUST00000125566
ENSMUST00000134994
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 108 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 108 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0004402 histone acetyltransferase activity
GO:0005515 protein binding
Biological Process
GO:0001932 regulation of protein phosphorylation
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007067 mitotic nuclear division
GO:0031063 regulation of histone deacetylation
GO:0031647 regulation of protein stability
GO:0043966 histone H3 acetylation
GO:0090043 regulation of tubulin deacetylation
Cellular Component
GO:0000125 PCAF complex
GO:0005634 nucleus
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex
GO:0005694 chromosome
GO:0072686 mitotic spindle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
null
View Gene Order
ENSBTAG00000014677
Not yet available
Pathways
NETPATH
REACTOME
REACT_218274
Chromatin organization pathway
REACT_226917
HATs acetylate histones pathway
REACT_202766
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_207632
Chromatin organization pathway
REACT_219482
HATs acetylate histones pathway
REACT_227044
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q8CHV6
TrEMBL B1AT25 Q3UQN9
UniProt Splice Variant
Entrez Gene 217031
UniGene Mm.45159
RefSeq NM_172562 XM_006532991
OMIM
CCDS CCDS25183
HPRD
IMGT
MGI ID MGI:2144471
MGI Symbol Tada2a
EMBL AK083467 AK142262 AK157938 AL596447 AL645615 BC025448 BC038821
GenPept AAH25448 AAH38821 BAC38925 BAE25000 BAE34272 CAI25269 CAI25507
RNA Seq Atlas 217031

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca