InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tada2a

Summary

InnateDB Protein

IDBP-205941.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tada2a

Protein Name

transcriptional adaptor 2A

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000018795

InnateDB Gene

IDBG-205939 (Tada2a)

Protein Structure

UniProt Annotation

Function

Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double- stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00624, ECO:0000269PubMed:16299514}. Chromosome {ECO:0000269PubMed:16299514}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 108 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	108 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0004402	histone acetyltransferase activity
GO:0005515	protein binding

Biological Process

GO:0001932	regulation of protein phosphorylation
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007067	mitotic nuclear division
GO:0031063	regulation of histone deacetylation
GO:0031647	regulation of protein stability
GO:0043966	histone H3 acetylation
GO:0090043	regulation of tubulin deacetylation