InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FNTA

Summary

InnateDB Gene

IDBG-20616.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FNTA

Gene Name

farnesyltransferase, CAAX box, alpha

Synonyms

FPTA; PGGT1A; PTAR2

Species

Homo sapiens

Ensembl Gene

ENSG00000168522

Encoded Proteins

IDBP-20618

farnesyltransferase, CAAX box, alpha

IDBP-598511

farnesyltransferase, CAAX box, alpha

IDBP-589118

farnesyltransferase, CAAX box, alpha

IDBP-584693

farnesyltransferase, CAAX box, alpha

IDBP-604025

farnesyltransferase, CAAX box, alpha

IDBP-583944

farnesyltransferase, CAAX box, alpha

IDBP-810818

farnesyltransferase, CAAX box, alpha

IDBP-603494

farnesyltransferase, CAAX box, alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Prenyltransferases can attach either a farnesyl group or a geranylgeranyl group in thioether linkage to the cysteine residue of proteins with a C-terminal CAAX box. CAAX geranylgeranyltransferase and CAAX farnesyltransferase are heterodimers that share the same alpha subunit but have different beta subunits. This gene encodes the alpha subunit of these transferases. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:43034194-43085788

Strand

Forward strand

Band

p11.21

Transcripts

ENST00000302279	ENSP00000303423
ENST00000533559
ENST00000526755	ENSP00000437208
ENST00000527153
ENST00000533383	ENSP00000435455
ENST00000533998	ENSP00000432892
ENST00000524546
ENST00000531266	ENSP00000432411
ENST00000533368
ENST00000525699	ENSP00000436998
ENST00000529687	ENSP00000473479
ENST00000533336	ENSP00000434430
ENST00000525099
ENST00000528400

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.

Experimentally validated
Total	19 [view]
Protein-Protein	18 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004660	protein farnesyltransferase activity
GO:0004661	protein geranylgeranyltransferase activity
GO:0004662	CAAX-protein geranylgeranyltransferase activity
GO:0004663	Rab geranylgeranyltransferase activity
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0008318	protein prenyltransferase activity
GO:0030548	acetylcholine receptor regulator activity
GO:0030971	receptor tyrosine kinase binding
GO:0043014	alpha-tubulin binding

Biological Process

GO:0006915	apoptotic process
GO:0006921	cellular component disassembly involved in execution phase of apoptosis
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007603	phototransduction, visible light
GO:0010469	regulation of receptor activity
GO:0016056	rhodopsin mediated signaling pathway
GO:0018342	protein prenylation
GO:0018343	protein farnesylation
GO:0018344	protein geranylgeranylation
GO:0022400	regulation of rhodopsin mediated signaling pathway
GO:0045213	neurotransmitter receptor metabolic process
GO:0090044	positive regulation of tubulin deacetylation
GO:0090045	positive regulation of deacetylase activity

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005875	microtubule associated complex
GO:0005953	CAAX-protein geranylgeranyltransferase complex
GO:0005965	protein farnesyltransferase complex