InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Fnta

Summary

InnateDB Gene

IDBG-144955.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fnta

Gene Name

farnesyltransferase, CAAX box, alpha

Synonyms

FTA

Species

Mus musculus

Ensembl Gene

ENSMUSG00000015994

Encoded Proteins

IDBP-144957

farnesyltransferase, CAAX box, alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168522:
Prenyltransferases can attach either a farnesyl group or a geranylgeranyl group in thioether linkage to the cysteine residue of proteins with a C-terminal CAAX box. CAAX geranylgeranyltransferase and CAAX farnesyltransferase are heterodimers that share the same alpha subunit but have different beta subunits. This gene encodes the alpha subunit of these transferases. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:25998729-26015601

Strand

Reverse strand

Band

Transcripts

ENSMUST00000016138

ENSMUSP00000016138

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004660	protein farnesyltransferase activity
GO:0004661	protein geranylgeranyltransferase activity
GO:0004662	CAAX-protein geranylgeranyltransferase activity
GO:0004663	Rab geranylgeranyltransferase activity
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0008318	protein prenyltransferase activity
GO:0030548	acetylcholine receptor regulator activity
GO:0030971	receptor tyrosine kinase binding
GO:0043014	alpha-tubulin binding

Biological Process

GO:0010469	regulation of receptor activity
GO:0018342	protein prenylation
GO:0018343	protein farnesylation
GO:0018344	protein geranylgeranylation
GO:0045213	neurotransmitter receptor metabolic process
GO:0090044	positive regulation of tubulin deacetylation
GO:0090045	positive regulation of deacetylase activity