InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Aatf

Summary

InnateDB Gene

IDBG-206233.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aatf

Gene Name

apoptosis antagonizing transcription factor

Synonyms

4933415H02Rik; 5830465M17Rik; Che-1; Trb

Species

Mus musculus

Ensembl Gene

ENSMUSG00000018697

Encoded Proteins

IDBP-206235

apoptosis antagonizing transcription factor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog null:
The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:84422855-84513522

Strand

Reverse strand

Band

Transcripts

ENSMUST00000018841	ENSMUSP00000018841
ENSMUST00000127042
ENSMUST00000141093
ENSMUST00000148434

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	33 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0043522	leucine zipper domain binding
GO:0044822	poly(A) RNA binding
GO:0048156	tau protein binding

Biological Process

GO:0006974	cellular response to DNA damage stimulus
GO:0007155	cell adhesion
GO:0007346	regulation of mitotic cell cycle
GO:0032929	negative regulation of superoxide anion generation
GO:0040016	embryonic cleavage
GO:0042254	ribosome biogenesis
GO:0042985	negative regulation of amyloid precursor protein biosynthetic process
GO:0043066	negative regulation of apoptotic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:2000378	negative regulation of reactive oxygen species metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005813	centrosome
GO:0005829	cytosol
GO:0005925	focal adhesion

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

null

View Gene Order

ENSBTAG00000021927

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_13638

NRAGE signals death through JNK pathway

REACT_11061

Signalling by NGF pathway

REACT_13776

p75 NTR receptor-mediated signalling pathway

REACT_111102

Signal Transduction pathway

REACT_13720

Cell death signalling via NRAGE, NRIF and NADE pathway

KEGG

INOH

PID NCI

rb_1pathway

Regulation of retinoblastoma protein

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.257482

RefSeq

NM_019816

OMIM

CCDS

CCDS25186

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas