InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Aatf

Summary

InnateDB Protein

IDBP-206235.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aatf

Protein Name

apoptosis antagonizing transcription factor

Synonyms

4933415H02Rik; 5830465M17Rik; Che-1; Trb;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000018841

InnateDB Gene

IDBG-206233 (Aatf)

Protein Structure

UniProt Annotation

Function

May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000269PubMed:11071758}.

Disease Associations

Tissue Specificity

Expressed in adrenal gland, brain (Purkinje cells), heart, kidney, liver, lung, muscle, ovary and testis (at the protein level). {ECO:0000269PubMed:11071758, ECO:0000269PubMed:14636992}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	33 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0043522	leucine zipper domain binding
GO:0044822	poly(A) RNA binding
GO:0048156	tau protein binding

Biological Process

GO:0006974	cellular response to DNA damage stimulus
GO:0007155	cell adhesion
GO:0007346	regulation of mitotic cell cycle
GO:0032929	negative regulation of superoxide anion generation
GO:0040016	embryonic cleavage
GO:0042254	ribosome biogenesis
GO:0042985	negative regulation of amyloid precursor protein biosynthetic process
GO:0043066	negative regulation of apoptotic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:2000378	negative regulation of reactive oxygen species metabolic process