Mus musculus Gene: Nop56
Summary
InnateDB Gene IDBG-206242.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nop56
Gene Name NOP56 ribonucleoprotein homolog (yeast)
Synonyms 2310044F10Rik; Nol5a
Species Mus musculus
Ensembl Gene ENSMUSG00000027405
Encoded Proteins
NOP56 ribonucleoprotein homolog (yeast)
NOP56 ribonucleoprotein homolog (yeast)
NOP56 ribonucleoprotein homolog (yeast)
NOP56 ribonucleoprotein homolog (yeast)
NOP56 ribonucleoprotein homolog (yeast)
NOP56 ribonucleoprotein homolog (yeast)
NOP56 ribonucleoprotein homolog (yeast)
NOP56 ribonucleoprotein homolog (yeast)
NOP56 ribonucleoprotein homolog (yeast)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101361:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] Nop56p is a yeast nucleolar protein that is part of a complex with the nucleolar proteins Nop58p and fibrillarin. Nop56p is required for assembly of the 60S ribosomal subunit and is involved in pre-rRNA processing. The protein encoded by this gene is similar in sequence to Nop56p and is also found in the nucleolus. Multiple transcript variants encoding several different isoforms have been found for this gene, but the full-length nature of most of them has not been determined. [provided by RefSeq, Jan 2009]
Nop56p is a yeast nucleolar protein that is part of a complex with the nucleolar proteins Nop58p and fibrillarin. Nop56p is required for assembly of the 60S ribosomal subunit and is involved in pre-rRNA processing. The protein encoded by this gene is similar in sequence to Nop56p and is also found in the nucleolus. Multiple transcript variants encoding several different isoforms have been found for this gene, but the full-length nature of most of them has not been determined. [provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:130274430-130279313
Strand Forward strand
Band F1
Transcripts
ENSMUST00000103198 ENSMUSP00000099487
ENSMUST00000028890 ENSMUSP00000028890
ENSMUST00000150745
ENSMUST00000161543
ENSMUST00000136621 ENSMUSP00000124616
ENSMUST00000141872 ENSMUSP00000125305
ENSMUST00000138163
ENSMUST00000160183
ENSMUST00000149955 ENSMUSP00000123879
ENSMUST00000160976
ENSMUST00000162063
ENSMUST00000143547 ENSMUSP00000124228
ENSMUST00000161025
ENSMUST00000146454 ENSMUSP00000125304
ENSMUST00000153353
ENSMUST00000150401 ENSMUSP00000123890
ENSMUST00000133351
ENSMUST00000159373 ENSMUSP00000124080
ENSMUST00000145335
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 104 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 104 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030515 snoRNA binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0008150 biological_process
GO:0042254 ribosome biogenesis
Cellular Component
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005732 small nucleolar ribonucleoprotein complex
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0070761 pre-snoRNP complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Chaperonin-mediated protein folding pathway
Association of TriC/CCT with target proteins during biosynthesis pathway
Metabolism of proteins pathway
Protein folding pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Association of TriC/CCT with target proteins during biosynthesis pathway
Protein folding pathway
Chaperonin-mediated protein folding pathway
Metabolism of proteins pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 67134
UniGene Mm.292497 Mm.29363 Mm.310528 Mm.313007 Mm.343997 Mm.388250
RefSeq NM_024193 XM_006500062
OMIM
CCDS CCDS16737
HPRD
IMGT
MGI ID MGI:1914384
MGI Symbol Nop56
EMBL
GenPept
RNA Seq Atlas 67134