Version 5.4
Homo sapiens Gene: NOP56
Summary
InnateDB Gene IDBG-42070.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NOP56
Gene Name NOP56 ribonucleoprotein homolog (yeast)
Synonyms NOL5A; SCA36
Species Homo sapiens
Ensembl Gene ENSG00000101361
Encoded Proteins
IDBP-42072
NOP56 ribonucleoprotein homolog (yeast)
IDBP-362775
NOP56 ribonucleoprotein homolog (yeast)
IDBP-362778
NOP56 ribonucleoprotein homolog (yeast)
IDBP-592434
NOP56 ribonucleoprotein homolog (yeast)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] Nop56p is a yeast nucleolar protein that is part of a complex with the nucleolar proteins Nop58p and fibrillarin. Nop56p is required for assembly of the 60S ribosomal subunit and is involved in pre-rRNA processing. The protein encoded by this gene is similar in sequence to Nop56p and is also found in the nucleolus. Multiple transcript variants encoding several different isoforms have been found for this gene, but the full-length nature of most of them has not been determined. [provided by RefSeq, Jan 2009]
Nop56p is a yeast nucleolar protein that is part of a complex with the nucleolar proteins Nop58p and fibrillarin. Nop56p is required for assembly of the 60S ribosomal subunit and is involved in pre-rRNA processing. The protein encoded by this gene is similar in sequence to Nop56p and is also found in the nucleolus. Multiple transcript variants encoding several different isoforms have been found for this gene, but the full-length nature of most of them has not been determined. [provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:2652145-2658393
Strand Forward strand
Band p13
Transcripts
ENST00000329276 ENSP00000370589
ENST00000445139 ENSP00000388497
ENST00000415272 ENSP00000403199
ENST00000494697
ENST00000470143
ENST00000469588
ENST00000460258
ENST00000496775
ENST00000480992
ENST00000484998
ENST00000467196 ENSP00000434317
ENST00000492135
ENST00000466447
ENST00000480447
ENST00000490753
ENST00000471023
ENST00000462630
ENST00000467857
ENST00000612233
ENST00000616692
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 147 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 147 [view]
Protein-Protein 147 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0030515 snoRNA binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006364 rRNA processing
GO:0008219 cell death
Cellular Component
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005732 small nucleolar ribonucleoprotein complex
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0031428 box C/D snoRNP complex
GO:0070761 pre-snoRNP complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027405
View Gene Order
ENSBTAG00000018812
Not yet available
Pathways
NETPATH
REACTOME
REACT_16907
Association of TriC/CCT with target proteins during biosynthesis pathway
REACT_16952
Protein folding pathway
REACT_17004
Chaperonin-mediated protein folding pathway
REACT_17015
Metabolism of proteins pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.598401
RefSeq NM_006392
HUGO
OMIM
CCDS CCDS13030
HPRD 10119
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca