InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ccr1

Summary

InnateDB Gene

IDBG-206525.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ccr1

Gene Name

chemokine (C-C motif) receptor 1

Synonyms

Cmkbr1; Mip-1a-R

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025804

Encoded Proteins

IDBP-206527

chemokine (C-C motif) receptor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163823:
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:123962126-123968692

Strand

Reverse strand

Band

Transcripts

ENSMUST00000026911

ENSMUSP00000026911

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0016493	C-C chemokine receptor activity
GO:0019957	C-C chemokine binding

Biological Process

GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0021549	cerebellum development
GO:0030099	myeloid cell differentiation
GO:0030595	leukocyte chemotaxis
GO:0031620	regulation of fever generation
GO:0032496	response to lipopolysaccharide
GO:0045824	negative regulation of innate immune response
GO:0070098	chemokine-mediated signaling pathway
GO:0090026	positive regulation of monocyte chemotaxis