InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ccr1

Summary

InnateDB Protein

IDBP-206527.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ccr1

Protein Name

chemokine (C-C motif) receptor 1

Synonyms

Cmkbr1; Mip-1a-R;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026911

InnateDB Gene

IDBG-206525 (Ccr1)

Protein Structure

UniProt Annotation

Function

Receptor for a C-C type chemokine. Binds to MIP-1-alpha, RANTES, and less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Detected in the heart, spleen, lung, peritoneal exudate cells and leukocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0016493	C-C chemokine receptor activity
GO:0019957	C-C chemokine binding

Biological Process

GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0021549	cerebellum development
GO:0030099	myeloid cell differentiation
GO:0030595	leukocyte chemotaxis
GO:0031620	regulation of fever generation
GO:0032496	response to lipopolysaccharide
GO:0045824	negative regulation of innate immune response
GO:0070098	chemokine-mediated signaling pathway
GO:0090026	positive regulation of monocyte chemotaxis

Cellular Component

GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0016021	integral component of membrane
GO:0043025	neuronal cell body

Protein Structure and Domains

PDB ID

MGI:104618

InterPro

IPR000248 Angiotensin II receptor family
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000355 Chemokine receptor family
IPR002236 CC chemokine receptor 1
IPR002238 CC chemokine receptor 3
IPR002240 CC chemokine receptor 5
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00241
PR00237
PR00657
PR01106
PR01108
PR01110

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P51675