InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Med13

Summary

InnateDB Gene

IDBG-206853.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Med13

Gene Name

mediator complex subunit 13

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000034297

Encoded Proteins

IDBP-206855

mediator complex subunit 13

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108510:
This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene is proposed to form a sub-complex with MED12, cyclin C, and CDK8 that can negatively regulate transactivation by mediator. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:86267033-86357602

Strand

Reverse strand

Band

Transcripts

ENSMUST00000043624	ENSMUSP00000044268
ENSMUST00000136622
ENSMUST00000140514
ENSMUST00000144983

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	41 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001104	RNA polymerase II transcription cofactor activity
GO:0003712	transcription cofactor activity
GO:0003713	transcription coactivator activity
GO:0004872	receptor activity
GO:0046966	thyroid hormone receptor binding

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0030518	intracellular steroid hormone receptor signaling pathway
GO:0030521	androgen receptor signaling pathway
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter