InnateDB Protein
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IDBP-206855.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Med13
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Protein Name
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mediator complex subunit 13
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000044268
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InnateDB Gene
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IDBG-206853 (Med13)
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Protein Structure
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Function |
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
|
Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
41 [view]
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Molecular Function |
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Biological Process |
GO:0006357
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regulation of transcription from RNA polymerase II promoter
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GO:0006367
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transcription initiation from RNA polymerase II promoter
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GO:0030518
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intracellular steroid hormone receptor signaling pathway
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GO:0030521
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androgen receptor signaling pathway
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GO:0045893
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positive regulation of transcription, DNA-templated
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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Cellular Component |
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PDB ID |
MGI:3029632
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InterPro |
IPR009401
Mediator complex, subunit Med13
IPR021643
Mediator complex, subunit Med13, N-terminal, metazoa/fungi
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PFAM |
PF06333
PF11597
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q5SWW4
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PhosphoSite |
PhosphoSite-Q5SWW4
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
327987
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UniGene |
Mm.472650
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RefSeq |
NP_001074400
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MGI ID |
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MGI Symbol |
Med13
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OMIM |
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CCDS |
CCDS36267
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HPRD |
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IMGT |
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EMBL |
AK037303
AK129168
AL592065
AL596256
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GenPept |
BAC97978
BAE20510
CAI24772
CAI25862
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