Version 5.4
Mus musculus Gene: Tead1
Summary
InnateDB Gene IDBG-207009.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tead1
Gene Name TEA domain family member 1
Synonyms 2610024B07Rik; B230114H05Rik; Gtrgeo5; mTEF-1; Tcf13; TEAD-1; TEF-1
Species Mus musculus
Ensembl Gene ENSMUSG00000055320
Encoded Proteins
IDBP-207011
TEA domain family member 1
IDBP-207013
TEA domain family member 1
IDBP-620114
TEA domain family member 1
IDBP-268354
TEA domain family member 1
IDBP-620106
TEA domain family member 1
IDBP-620107
TEA domain family member 1
IDBP-620108
TEA domain family member 1
IDBP-620109
TEA domain family member 1
IDBP-620110
TEA domain family member 1
IDBP-620111
TEA domain family member 1
IDBP-620112
TEA domain family member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000187079:
This gene encodes a ubiquitous transcriptional enhancer factor that is a member of the TEA/ATTS domain family. This protein directs the transactivation of a wide variety of genes and, in placental cells, also acts as a transcriptional repressor. Mutations in this gene cause Sveinsson's chorioretinal atrophy. Additional transcript variants have been described but their full-length natures have not been experimentally verified. [provided by RefSeq, May 2010]
This gene encodes a ubiquitous transcriptional enhancer factor that is a member of the TEA/ATTS domain family. This protein directs the transactivation of a wide variety of genes and, in placental cells, also acts as a transcriptional repressor. Mutations in this gene cause Sveinsson\'s chorioretinal atrophy. Additional transcript variants have been described but their full-length natures have not been experimentally verified. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:112679318-112906807
Strand Forward strand
Band F1
Transcripts
ENSMUST00000059768 ENSMUSP00000060671
ENSMUST00000084705 ENSMUSP00000081755
ENSMUST00000069256 ENSMUSP00000130459
ENSMUST00000106638 ENSMUSP00000102249
ENSMUST00000172065
ENSMUST00000171373 ENSMUSP00000131765
ENSMUST00000164363 ENSMUSP00000127574
ENSMUST00000163593
ENSMUST00000170352 ENSMUSP00000129798
ENSMUST00000168981 ENSMUSP00000133025
ENSMUST00000171197 ENSMUSP00000128439
ENSMUST00000165036 ENSMUSP00000131221
ENSMUST00000167060 ENSMUSP00000130564
ENSMUST00000168328
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
Biological Process
GO:0003143 embryonic heart tube morphogenesis
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007507 heart development
GO:0030903 notochord development
GO:0035329 hippo signaling
GO:0042127 regulation of cell proliferation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048339 paraxial mesoderm development
GO:0048368 lateral mesoderm development
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000187079
View Gene Order
ENSBTAG00000032657
Not yet available
Pathways
NETPATH
REACTOME
REACT_256522
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_257219
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_233572
Gene Expression pathway
REACT_198602
PPARA activates gene expression pathway
REACT_196516
YAP1- and WWTR1 (TAZ)-stimulated gene expression pathway
REACT_206529
Generic Transcription Pathway pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q3USK5
UniProt Splice Variant
Entrez Gene 21676
UniGene Mm.24685 Mm.398985 Mm.399673 Mm.453524 Mm.472413
RefSeq NM_001166584 NM_001166585 NM_009346 XM_006507561 XM_006507562 XM_006507563
OMIM
CCDS CCDS52365 CCDS52366 CCDS52367
HPRD
IMGT
MGI ID MGI:101876
MGI Symbol Tead1
EMBL AC104930 AC126052 AC155930 AK140307
GenPept BAE24326
RNA Seq Atlas 21676

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca