Version 5.4
Homo sapiens Gene: TEAD1
Summary
InnateDB Gene IDBG-32520.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TEAD1
Gene Name TEA domain family member 1 (SV40 transcriptional enhancer factor)
Synonyms AA; NTEF-1; REF1; TCF-13; TCF13; TEAD-1; TEF-1
Species Homo sapiens
Ensembl Gene ENSG00000187079
Encoded Proteins
IDBP-32522
TEA domain family member 1 (SV40 transcriptional enhancer factor)
IDBP-32524
TEA domain family member 1 (SV40 transcriptional enhancer factor)
IDBP-593271
TEA domain family member 1 (SV40 transcriptional enhancer factor)
IDBP-603561
TEA domain family member 1 (SV40 transcriptional enhancer factor)
IDBP-598733
TEA domain family member 1 (SV40 transcriptional enhancer factor)
IDBP-598625
TEA domain family member 1 (SV40 transcriptional enhancer factor)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a ubiquitous transcriptional enhancer factor that is a member of the TEA/ATTS domain family. This protein directs the transactivation of a wide variety of genes and, in placental cells, also acts as a transcriptional repressor. Mutations in this gene cause Sveinsson's chorioretinal atrophy. Additional transcript variants have been described but their full-length natures have not been experimentally verified. [provided by RefSeq, May 2010]
This gene encodes a ubiquitous transcriptional enhancer factor that is a member of the TEA/ATTS domain family. This protein directs the transactivation of a wide variety of genes and, in placental cells, also acts as a transcriptional repressor. Mutations in this gene cause Sveinsson\'s chorioretinal atrophy. Additional transcript variants have been described but their full-length natures have not been experimentally verified. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:12674591-12944483
Strand Forward strand
Band p15.3
Transcripts
ENST00000334310 ENSP00000334754
ENST00000361985 ENSP00000354588
ENST00000527636 ENSP00000435233
ENST00000527376 ENSP00000432587
ENST00000527575 ENSP00000435977
ENST00000525312
ENST00000526600 ENSP00000435393
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
Biological Process
GO:0003143 embryonic heart tube morphogenesis
GO:0006355 regulation of transcription, DNA-templated
GO:0007507 heart development
GO:0030903 notochord development
GO:0035329 hippo signaling
GO:0042127 regulation of cell proliferation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048339 paraxial mesoderm development
GO:0048368 lateral mesoderm development
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000055320
View Gene Order
ENSBTAG00000032657
Not yet available
Cross-References
SwissProt
TrEMBL H0YCZ6
UniProt Splice Variant
Entrez Gene 7003
UniGene Hs.635965 Hs.639189 Hs.655331
RefSeq NM_021961
HUGO HGNC:11714
OMIM 189967
CCDS CCDS7810
HPRD 01802
IMGT
EMBL AC013549 AC084859 AC107881
GenPept
RNA Seq Atlas 7003

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca