InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cltc

Summary

InnateDB Gene

IDBG-207019.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cltc

Gene Name

clathrin, heavy polypeptide (Hc)

Synonyms

3110065L21Rik; CHC; R74732

Species

Mus musculus

Ensembl Gene

ENSMUSG00000047126

Encoded Proteins

IDBP-207021

clathrin, heavy polypeptide (Hc)

IDBP-207023

clathrin, heavy polypeptide (Hc)

IDBP-542279

clathrin, heavy polypeptide (Hc)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21364927

Cltc functions as a built-in molecular brake that ensures a tight control of basal NFKB activation and gene expression in un-stimulated cells. Defects in Cltc expression could potentially lead to chronic inflammation disorder.

InnateDB Annotation from Orthologs

Summary

PMID 21364927

[Homo sapiens] CLTC functions as a built-in molecular brake that ensures a tight control of basal NFKB activation and gene expression in un-stimulated cells. Defects in CLTC expression could potentially lead to chronic inflammation disorder.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000141367:
Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains. [provided by RefSeq, Jul 2008]
Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:86694351-86757565

Strand

Reverse strand

Band

Transcripts

ENSMUST00000103186	ENSMUSP00000099475
ENSMUST00000060766	ENSMUSP00000050220
ENSMUST00000124385	ENSMUSP00000117674
ENSMUST00000134999
ENSMUST00000141152
ENSMUST00000133501

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 135 interaction(s) predicted by orthology.

Experimentally validated
Total	40 [view]
Protein-Protein	40 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	135 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003725	double-stranded RNA binding
GO:0005198	structural molecule activity
GO:0005488	binding
GO:0032051	clathrin light chain binding

Biological Process

GO:0006886	intracellular protein transport
GO:0016192	vesicle-mediated transport
GO:0031623	receptor internalization
GO:0033572	transferrin transport
GO:0045087	innate immune response (InnateDB)
GO:0090307	spindle assembly involved in mitosis
GO:1900126	negative regulation of hyaluronan biosynthetic process

Cellular Component

GO:0005739	mitochondrion
GO:0005819	spindle
GO:0030117	membrane coat
GO:0030130	clathrin coat of trans-Golgi network vesicle
GO:0030132	clathrin coat of coated pit
GO:0031523	Myb complex
GO:0042470	melanosome
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome
GO:0071439	clathrin complex