InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Arntl

Summary

InnateDB Gene

IDBG-207053.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Arntl

Gene Name

aryl hydrocarbon receptor nuclear translocator-like

Synonyms

Arnt3; bHLHe5; Bmal1; BMAL1b; bmal1b\'; MOP3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000055116

Encoded Proteins

IDBP-207055

aryl hydrocarbon receptor nuclear translocator-like

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with Clock. This heterodimer binds E-box enhancer elements upstream of Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2) genes and activates transcription of these genes. Per and Cry proteins heterodimerize and repress their own transcription by interacting in a feedback loop with Clock/Arntl complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:113207465-113314122

Strand

Forward strand

Band

Transcripts

ENSMUST00000047321

ENSMUSP00000046235

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	44 [view]
Protein-Protein	41 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	1 [view]

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0000982	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
GO:0001047	core promoter binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001190	RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0017162	aryl hydrocarbon receptor binding
GO:0043425	bHLH transcription factor binding
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity
GO:0051879	Hsp90 protein binding
GO:0070888	E-box binding

Biological Process

GO:0000060	protein import into nucleus, translocation
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007165	signal transduction
GO:0007283	spermatogenesis
GO:0007623	circadian rhythm
GO:0032007	negative regulation of TOR signaling
GO:0032922	circadian regulation of gene expression
GO:0042176	regulation of protein catabolic process
GO:0042634	regulation of hair cycle
GO:0042753	positive regulation of circadian rhythm
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045087	innate immune response
GO:0045599	negative regulation of fat cell differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050767	regulation of neurogenesis
GO:0050796	regulation of insulin secretion
GO:0051726	regulation of cell cycle
GO:0051775	response to redox state
GO:0090263	positive regulation of canonical Wnt signaling pathway
GO:0090403	oxidative stress-induced premature senescence
GO:2000074	regulation of type B pancreatic cell development
GO:2000323	negative regulation of glucocorticoid receptor signaling pathway
GO:2000772	regulation of cellular senescence
GO:2001016	positive regulation of skeletal muscle cell differentiation

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex
GO:0005829	cytosol
GO:0016604	nuclear body
GO:0016605	PML body
GO:0033391	chromatoid body