Version 5.4
Homo sapiens Gene: ARNTL
Summary
InnateDB Gene IDBG-32620.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARNTL
Gene Name aryl hydrocarbon receptor nuclear translocator-like
Synonyms bHLHe5; BMAL1; BMAL1c; JAP3; MOP3; PASD3; TIC
Species Homo sapiens
Ensembl Gene ENSG00000133794
Encoded Proteins
IDBP-32626
aryl hydrocarbon receptor nuclear translocator-like
IDBP-294313
aryl hydrocarbon receptor nuclear translocator-like
IDBP-294299
aryl hydrocarbon receptor nuclear translocator-like
IDBP-294308
aryl hydrocarbon receptor nuclear translocator-like
IDBP-294312
aryl hydrocarbon receptor nuclear translocator-like
IDBP-591949
aryl hydrocarbon receptor nuclear translocator-like
IDBP-602986
aryl hydrocarbon receptor nuclear translocator-like
IDBP-592100
aryl hydrocarbon receptor nuclear translocator-like
IDBP-586331
aryl hydrocarbon receptor nuclear translocator-like
IDBP-598453
aryl hydrocarbon receptor nuclear translocator-like
IDBP-587685
aryl hydrocarbon receptor nuclear translocator-like
IDBP-595117
aryl hydrocarbon receptor nuclear translocator-like
IDBP-583721
aryl hydrocarbon receptor nuclear translocator-like
IDBP-586422
aryl hydrocarbon receptor nuclear translocator-like
IDBP-593186
aryl hydrocarbon receptor nuclear translocator-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This complex binds an E-box upstream of the PER1 gene, activating this gene and possibly other circadian rhythym-associated genes. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:13276652-13387266
Strand Forward strand
Band p15.3
Transcripts
ENST00000389707 ENSP00000374357
ENST00000403290 ENSP00000384517
ENST00000401424 ENSP00000385915
ENST00000403510 ENSP00000385581
ENST00000403482 ENSP00000385897
ENST00000485918
ENST00000480685
ENST00000482049 ENSP00000436721
ENST00000497429
ENST00000472842
ENST00000529050 ENSP00000434044
ENST00000534544 ENSP00000431566
ENST00000527998 ENSP00000433540
ENST00000533520 ENSP00000431488
ENST00000529825 ENSP00000434263
ENST00000529388 ENSP00000433571
ENST00000530357 ENSP00000436313
ENST00000531665 ENSP00000434781
ENST00000534102
ENST00000529390
ENST00000524392 ENSP00000436442
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Experimentally validated
Total 34 [view]
Protein-Protein 28 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 5 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000976 transcription regulatory region sequence-specific DNA binding
GO:0000982 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
GO:0001047 core promoter binding
GO:0001190 RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0017162 aryl hydrocarbon receptor binding
GO:0043425 bHLH transcription factor binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0051879 Hsp90 protein binding
GO:0070888 E-box binding
Biological Process
GO:0000060 protein import into nucleus, translocation
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007165 signal transduction
GO:0007283 spermatogenesis
GO:0007623 circadian rhythm
GO:0032007 negative regulation of TOR signaling
GO:0032922 circadian regulation of gene expression
GO:0042176 regulation of protein catabolic process
GO:0042634 regulation of hair cycle
GO:0042753 positive regulation of circadian rhythm
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045599 negative regulation of fat cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050767 regulation of neurogenesis
GO:0050796 regulation of insulin secretion
GO:0051726 regulation of cell cycle
GO:0051775 response to redox state
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0090403 oxidative stress-induced premature senescence
GO:2000074 regulation of type B pancreatic cell development
GO:2000323 negative regulation of glucocorticoid receptor signaling pathway
GO:2000772 regulation of cellular senescence
GO:2001016 positive regulation of skeletal muscle cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0016604 nuclear body
GO:0016605 PML body
GO:0033391 chromatoid body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000055116
View Gene Order
ENSBTAG00000013029
Not yet available
Pathways
NETPATH
REACTOME
REACT_116145
PPARA activates gene expression pathway
REACT_19241
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_118659
RORA activates circadian gene expression pathway
REACT_111118
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
REACT_118789
REV-ERBA represses gene expression pathway
REACT_24941
Circadian Clock pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
hsa04710
Circadian rhythm pathway
INOH
PID NCI
circadianpathway
Circadian rhythm pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.65734
RefSeq NM_001030272 NM_001030273 NM_001178 NM_001297719 NM_001297722 NM_001297724 XM_005252928 XM_005252929 XM_005252930 XM_006718233 XM_006718234 XM_006718235
HUGO
OMIM
CCDS CCDS31430 CCDS44543 CCDS73259
HPRD 03973
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca