Mus musculus Gene: Mavs
Summary
InnateDB Gene IDBG-207066.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mavs
Gene Name mitochondrial antiviral signaling protein
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000037523
Encoded Proteins
mitochondrial antiviral signaling protein
mitochondrial antiviral signaling protein
mitochondrial antiviral signaling protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
The Mavs signalling pathway in non-myeloid cells is crucial for dsRNA-mediated natural killer cell activation.
Tyrosine phosphorylation of Mavs at amino acid residue Tyr9 is critical for the induction of Ifnb signalling. (Demonstrated in human)
Upon infection with encephalitic Bunyavirus, RIG-I/MAVS signalling activates SARM1 to mediate neuronal cell death.
MAVS binds to VDAC1 to trigger viral-induced apoptosis.
Plasmodium RNA is a pathogen-associated molecular pattern (PAMP) capable of activating a type I IFN response via the cytosolic pattern recognition receptors Ifih1 and Mavs, as well as via transcription factors Irf3 and Irf7.
Antiviral response to rotavirus in infected macrophages is fully Mavs-dependent.
Alveolar macrophages detect respiratory syncytial virus (RSV) via the Mavs /Ddx58 pathway and are a major source of type I interferons upon RSV infection.
Transgenic picornavirus RNA-dependent RNA polymerase (RdRP) expression in mice produces a quantitatively dramatic, sustained, effective antiviral interferon-stimulated genes (ISG) network, which requires the MDA5-MAVS pathway.
March5 modulates Mavs-mediated antiviral signalling, preventing excessive immune reactions.
Baiap2l1 recruits Ube2i to sumoylate Pcbp2, which causes its cytoplasmic translocation during viral infection and the sumoylated Pcbp2 associates with Mavs to initiate its degradation, leading to downregulation of antiviral responses.
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] MAVS oligomer is essential in the formation of a multiprotein membrane-associated signalling complex that enables downstream activation of IRF3 and NF-kappaB in antiviral innate immunity.
[Homo sapiens] MAVS is a caspase recruitment domain (CARD)-containing adaptor protein that interacts with DDX58 (RIG-I) and recruits CHUK (IKKalpha), IKBKB (IKKbeta) and IKBKE (IKKepsilon) kinases by means of its C-terminal region, leading to the activation of NF-kappaB and IRF3.
[Homo sapiens] MAVS is an adaptor protein that contains an N-terminal caspase recruitment domain (CARD)-like domain and a C-terminal transmembrane domain, both of which are essential for MAVS signalling, while the transmembrane domain also targets MAVS to the mitochondria.
[Homo sapiens] MAVS facilitates cell death by disrupting the mitochondrial membrane potential and by activating caspases.
[Homo sapiens] MAVS-dependent RIG-I-like receptor (RLR) signalling regulates the quantity, quality, and balance of the immune response to West Nile virus (WNV) infection.
[Homo sapiens] MAVS in peroxisomes induces a rapid interferon-independent expression of defence factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signalling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response.
[Homo sapiens] MAVS interacts with hepatitis B virus X protein and this promotes the degradation of MAVS via Lys(136) ubiquitination, preventing the induction of IFN-beta.
[Homo sapiens] MAVS (IPS-1) interacts with MFN1 upon virus-infection or 5'ppp-RNA activation through redistribution of MAVS to form speck-like aggregates in cells.
[Homo sapiens] MAVS (IPS1) plays an important role in regulating the host anti-viral response by binding to viral polymerase and inhibiting IFN-beta production.
[Homo sapiens] MAVS negatively regulates the stability of voltage-dependent anion channel 1 (VDAC1) and thereby inhibits apoptosis in the response to release of cytochrome c.
[Homo sapiens] The MAVS signalling pathway in non-myeloid cells is crucial for dsRNA-mediated natural killer cell activation. (Demonstrated in murine model)
[Homo sapiens] Tyrosine phosphorylation of MAVS at amino acid residue Tyr9 is critical for the induction of IFNB signalling.
[Homo sapiens] MAVS mRNA is degraded in response to foreign RNA and poly(I:C) to suppress hyper-immune reaction in late-phase antiviral signalling.
[Homo sapiens] MAVS is required for optimal NLRP3 inflammasome activity by mediating mitochondrial recruitment of NLRP3.
[Homo sapiens] MAVS is targeted by enterovirus protease to evade antiviral immunity.
[Homo sapiens] The binding of MAVS to Traf2, Traf5, and Traf6 is dependent on virus infection and MAVS polymerization. The TRAF proteins promote ubiquitination that recruits IKBKG binding to the MAVS signalling complex.
[Homo sapiens] Upon viral infection, MAVS recruits MKK7 onto mitochondria, leading to the induction of apoptosis by MAP2K7 activated MAPK9
[Homo sapiens] Macrocyclic NS3-4A resistance-associated amino acid variants (RAVs) with substitutions at residue D168 of the hepatitis C virus protease result in an increased capacity of NS3-4A to cleave MAVS and suppress IFNB1 induction.
[Homo sapiens] RNA cleavage products, catalyzed by RNASEL, bind to DHX33 to facilitate the formation of a complex with MAVS and NLRP3 during viral infection.
[Homo sapiens] HACE1 plays an inhibitory role in virus-induced signalling by disrupting the MAVS-TRAF3 complex.
[Homo sapiens] MARCH5 modulates MAVS-mediated antiviral signalling, preventing excessive immune reactions.
[Homo sapiens] MAVS directly interacts with TRAF6 through its potential TRAF6-binding motif 2.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000088888:
This gene encodes an intermediary protein necessary in the virus-triggered beta interferon signaling pathways. It is required for activation of transcription factors which regulate expression of beta interferon and contributes to antiviral immunity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:131234063-131248025
Strand Forward strand
Band F1
Transcripts
ENSMUST00000041362 ENSMUSP00000038339
ENSMUST00000110199 ENSMUSP00000105828
ENSMUST00000130597 ENSMUSP00000138401
ENSMUST00000132694
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 91 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 25 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 91 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0050700 CARD domain binding
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0002218 activation of innate immune response
GO:0002230 positive regulation of defense response to virus by host
GO:0007165 signal transduction
GO:0032481 positive regulation of type I interferon production
GO:0032727 positive regulation of interferon-alpha production
GO:0032728 positive regulation of interferon-beta production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0033160 positive regulation of protein import into nucleus, translocation
GO:0039529 RIG-I signaling pathway
GO:0042742 defense response to bacterium
GO:0042993 positive regulation of transcription factor import into nucleus
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045071 negative regulation of viral genome replication
GO:0045087 innate immune response (InnateDB)
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051607 defense response to virus
GO:0060340 positive regulation of type I interferon-mediated signaling pathway
GO:0071360 cellular response to exogenous dsRNA
GO:0071651 positive regulation of chemokine (C-C motif) ligand 5 production
GO:0071660 positive regulation of IP-10 production
GO:1900063 regulation of peroxisome organization
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005777 peroxisome
GO:0005778 peroxisomal membrane
GO:0016021 integral component of membrane
GO:0031966 mitochondrial membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
TRAF6 mediated NF-kB activation pathway
Innate Immune System pathway
Negative regulators of RIG-I/MDA5 signaling pathway
Immune System pathway
TRAF6 mediated IRF7 activation pathway
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
TRAF3-dependent IRF activation pathway pathway
KEGG
RIG-I-like receptor signaling pathway pathway
Cytosolic DNA-sensing pathway pathway
Hepatitis C pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Innate Immune System pathway
TRAF6 mediated IRF7 activation pathway
TRAF6 mediated NF-kB activation pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 pathway
Immune System pathway
TRAF3-dependent IRF activation pathway pathway
Negative regulators of RIG-I/MDA5 signaling pathway
KEGG
RIG-I-like receptor signaling pathway pathway
Cytosolic DNA-sensing pathway pathway
Hepatitis C pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q8VCF0
TrEMBL Q3U5B1
UniProt Splice Variant
Entrez Gene 228607
UniGene Mm.287226 Mm.402894 Mm.488165
RefSeq NM_001206382 NM_001206383 NM_001206385 NM_144888
OMIM
CCDS CCDS16760
HPRD
IMGT
MGI ID MGI:2444773
MGI Symbol Mavs
EMBL AK028421 AK153748 BC020006 BC025825 BC031352 BC037391 DQ167127 DQ174271
GenPept AAH20006 AAH25825 AAH31352 AAH37391 AAZ80418 ABA54891 BAC25940 BAE32168
RNA Seq Atlas 228607