InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mavs

Summary

InnateDB Protein

IDBP-207068.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mavs

Protein Name

mitochondrial antiviral signaling protein

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000038339

InnateDB Gene

IDBG-207066 (Mavs)

Protein Structure

UniProt Annotation

Function

Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon- independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon- dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion outer membrane {ECO:0000250}. Mitochondrion {ECO:0000250}. Peroxisome {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 91 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	91 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0050700	CARD domain binding

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0002230	positive regulation of defense response to virus by host
GO:0007165	signal transduction
GO:0032481	positive regulation of type I interferon production
GO:0032727	positive regulation of interferon-alpha production
GO:0032728	positive regulation of interferon-beta production
GO:0032757	positive regulation of interleukin-8 production
GO:0032760	positive regulation of tumor necrosis factor production
GO:0033160	positive regulation of protein import into nucleus, translocation
GO:0039529	RIG-I signaling pathway
GO:0042742	defense response to bacterium
GO:0042993	positive regulation of transcription factor import into nucleus
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045071	negative regulation of viral genome replication
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060340	positive regulation of type I interferon-mediated signaling pathway
GO:0071360	cellular response to exogenous dsRNA
GO:0071651	positive regulation of chemokine (C-C motif) ligand 5 production
GO:0071660	positive regulation of IP-10 production
GO:1900063	regulation of peroxisome organization

Cellular Component

GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005777	peroxisome
GO:0005778	peroxisomal membrane
GO:0016021	integral component of membrane