InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pank2

Summary

InnateDB Gene

IDBG-207069.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pank2

Gene Name

pantothenate kinase 2

Synonyms

4933409I19Rik; AI642621

Species

Mus musculus

Ensembl Gene

ENSMUSG00000037514

Encoded Proteins

IDBP-540624

pantothenate kinase 2

IDBP-535597

pantothenate kinase 2

IDBP-789835

pantothenate kinase 2

IDBP-789836

pantothenate kinase 2

IDBP-789837

pantothenate kinase 2

IDBP-789838

pantothenate kinase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125779:
This gene encodes a protein belonging to the pantothenate kinase family and is the only member of that family to be expressed in mitochondria. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by acyl CoA species. Mutations in this gene are associated with HARP syndrome and pantothenate kinase-associated neurodegeneration (PKAN), formerly Hallervorden-Spatz syndrome. Alternative splicing, involving the use of alternate first exons, results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:131262495-131299188

Strand

Forward strand

Band

Transcripts

ENSMUST00000131779
ENSMUST00000150843	ENSMUSP00000119606
ENSMUST00000145904	ENSMUSP00000115034
ENSMUST00000138509
ENSMUST00000184105	ENSMUSP00000138992
ENSMUST00000184932	ENSMUSP00000139259
ENSMUST00000183388	ENSMUSP00000139197
ENSMUST00000183349	ENSMUSP00000139203

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004594	pantothenate kinase activity
GO:0005524	ATP binding

Biological Process

GO:0007286	spermatid development
GO:0009060	aerobic respiration
GO:0015937	coenzyme A biosynthetic process
GO:0016310	phosphorylation
GO:0051881	regulation of mitochondrial membrane potential
GO:0070584	mitochondrion morphogenesis