InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PANK2

Summary

InnateDB Gene

IDBG-640025.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PANK2

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000007920

Encoded Proteins

IDBP-692229

pantothenate kinase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125779:
This gene encodes a protein belonging to the pantothenate kinase family and is the only member of that family to be expressed in mitochondria. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by acyl CoA species. Mutations in this gene are associated with HARP syndrome and pantothenate kinase-associated neurodegeneration (PKAN), formerly Hallervorden-Spatz syndrome. Alternative splicing, involving the use of alternate first exons, results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:51736324-51765187

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000045589

ENSBTAP00000042968

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004594	pantothenate kinase activity
GO:0005524	ATP binding

Biological Process

GO:0007286	spermatid development
GO:0009060	aerobic respiration
GO:0015937	coenzyme A biosynthetic process
GO:0016310	phosphorylation
GO:0051881	regulation of mitochondrial membrane potential
GO:0070584	mitochondrion morphogenesis