InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pth

Summary

InnateDB Gene

IDBG-207092.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pth

Gene Name

parathyroid hormone

Synonyms

Pthp

Species

Mus musculus

Ensembl Gene

ENSMUSG00000059077

Encoded Proteins

IDBP-207094

parathyroid hormone

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000152266:
The protein encoded by this gene is a hormone secreted by parathyroid cells. This hormone elevates blood Ca2+ level by dissolving the salts in bone and preventing their renal excretion. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH). [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:113385576-113388573

Strand

Reverse strand

Band

Transcripts

ENSMUST00000079793

ENSMUSP00000078723

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005179	hormone activity
GO:0031856	parathyroid hormone receptor binding
GO:0031857	type 1 parathyroid hormone receptor binding
GO:0051428	peptide hormone receptor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006874	cellular calcium ion homeostasis
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007266	Rho protein signal transduction
GO:0007267	cell-cell signaling
GO:0009967	positive regulation of signal transduction
GO:0010288	response to lead ion
GO:0010468	regulation of gene expression
GO:0030501	positive regulation of bone mineralization
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0031667	response to nutrient levels
GO:0033280	response to vitamin D
GO:0034645	cellular macromolecule biosynthetic process
GO:0042493	response to drug
GO:0045471	response to ethanol
GO:0045725	positive regulation of glycogen biosynthetic process
GO:0045778	positive regulation of ossification
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046326	positive regulation of glucose import
GO:0046686	response to cadmium ion
GO:0071107	response to parathyroid hormone
GO:0071774	response to fibroblast growth factor