InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cyp2r1

Summary

InnateDB Gene

IDBG-207253.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cyp2r1

Gene Name

cytochrome P450, family 2, subfamily r, polypeptide 1

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030670

Encoded Proteins

IDBP-207255

cytochrome P450, family 2, subfamily r, polypeptide 1

IDBP-400282

cytochrome P450, family 2, subfamily r, polypeptide 1

IDBP-536838

cytochrome P450, family 2, subfamily r, polypeptide 1

IDBP-538468

cytochrome P450, family 2, subfamily r, polypeptide 1

IDBP-538178

cytochrome P450, family 2, subfamily r, polypeptide 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000186104:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is a microsomal vitamin D hydroxylase that converts vitamin D into the active ligand for the vitamin D receptor. A mutation in this gene has been associated with selective 25-hydroxyvitamin D deficiency. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:114550166-114562972

Strand

Reverse strand

Band

Transcripts

ENSMUST00000032908	ENSMUSP00000032908
ENSMUST00000119712	ENSMUSP00000112818
ENSMUST00000138712	ENSMUSP00000123556
ENSMUST00000133484
ENSMUST00000128587	ENSMUSP00000121924
ENSMUST00000147428	ENSMUSP00000119605

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0005506	iron ion binding
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding
GO:0030343	vitamin D3 25-hydroxylase activity
GO:0047749	cholestanetriol 26-monooxygenase activity

Biological Process

GO:0010164	response to cesium ion
GO:0010212	response to ionizing radiation
GO:0036378	calcitriol biosynthetic process from calciol
GO:0042359	vitamin D metabolic process
GO:0055114	oxidation-reduction process