InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CYP2R1

Summary

InnateDB Gene

IDBG-632795.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP2R1

Gene Name

vitamin D 25-hydroxylase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000010419

Encoded Proteins

IDBP-684496

vitamin D 25-hydroxylase

IDBP-684499

vitamin D 25-hydroxylase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000186104:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is a microsomal vitamin D hydroxylase that converts vitamin D into the active ligand for the vitamin D receptor. A mutation in this gene has been associated with selective 25-hydroxyvitamin D deficiency. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:38420926-38445583

Strand

Forward strand

Band

Transcripts

ENSBTAT00000039972	ENSBTAP00000039756
ENSBTAT00000013747	ENSBTAP00000013747

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0005506	iron ion binding
GO:0016491	oxidoreductase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding
GO:0030343	vitamin D3 25-hydroxylase activity
GO:0046872	metal ion binding