Version 5.4
| Mus musculus Gene: C330006K01Rik | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-207275.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | C330006K01Rik | ||||||||
| Gene Name | RIKEN cDNA C330006K01 gene | ||||||||
| Synonyms | |||||||||
| Species | Mus musculus | ||||||||
| Ensembl Gene | ENSMUSG00000039623 | ||||||||
| Encoded Proteins |
RIKEN cDNA C330006K01 gene
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000242802:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] This gene was identified by genome-wide screen for genes involved in homologous recombination DNA double-strand break repair (HR-DSBR). The encoded protein was found in a complex with other proteins that have a role in HR-DSBR. Knockdown of this gene reduced homologous recombination, and mutations in this gene were found in patients with spastic paraplegia. It was concluded that this gene likely encodes a helicase (PMID:20613862). [provided by RefSeq, Jan 2011] This gene was identified by genome-wide screen for genes involved in homologous recombination DNA double-strand break repair (HR-DSBR). The encoded protein was found in a complex with other proteins that have a role in HR-DSBR. Knockdown of this gene reduced homologous recombination, and mutations in this gene were found in patients with spastic paraplegia. It was concluded that this gene likely encodes a helicase (PMID:20613862). [provided by RefSeq, Jan 2011] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 5:142463931-142478715 | ||||||||
| Strand | Forward strand | ||||||||
| Band | G2 | ||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Cross-References | |||||||||
| SwissProt | Q3U829 | ||||||||
| TrEMBL | B7ZMR5 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 231855 | ||||||||
| UniGene | Mm.414289 | ||||||||
| RefSeq | NM_172725 XM_006504679 XM_006504680 XM_006504681 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS39361 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| MGI ID | MGI:1924908 | ||||||||
| MGI Symbol | Ap5z1 | ||||||||
| EMBL | AK040924 AK082759 AK146431 AK152402 BC082786 BC144755 | ||||||||
| GenPept | AAH82786 AAI44756 BAC30747 BAC38605 BAE27165 BAE31190 | ||||||||
| RNA Seq Atlas | 231855 | ||||||||