InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: KIAA0415

Summary

InnateDB Gene

IDBG-641144.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KIAA0415

Gene Name

protein KIAA0415 homolog

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000012197

Encoded Proteins

IDBP-693503

Uncharacterized protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000242802:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] This gene was identified by genome-wide screen for genes involved in homologous recombination DNA double-strand break repair (HR-DSBR). The encoded protein was found in a complex with other proteins that have a role in HR-DSBR. Knockdown of this gene reduced homologous recombination, and mutations in this gene were found in patients with spastic paraplegia. It was concluded that this gene likely encodes a helicase (PMID:20613862). [provided by RefSeq, Jan 2011]
This gene was identified by genome-wide screen for genes involved in homologous recombination DNA double-strand break repair (HR-DSBR). The encoded protein was found in a complex with other proteins that have a role in HR-DSBR. Knockdown of this gene reduced homologous recombination, and mutations in this gene were found in patients with spastic paraplegia. It was concluded that this gene likely encodes a helicase (PMID:20613862). [provided by RefSeq, Jan 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 25:39736450-39742348

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000016176

ENSBTAP00000016176

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000724	double-strand break repair via homologous recombination
GO:0016197	endosomal transport

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0044599	AP-5 adaptor complex

Orthologs

Species

Mus musculus

Homo sapiens

Gene ID

Gene Order

ENSMUSG00000039623

View Gene Order

ENSG00000242802

View Gene Order

Cross-References

SwissProt

TrEMBL

A7YVI7 F1MZR9

UniProt Splice Variant

Entrez Gene

512522

UniGene

Bt.107452

RefSeq

XM_005225083 XM_005225084 XM_005225085 XM_005225086

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC123866 DAAA02058362

GenPept

AAI23867

RNA Seq Atlas

512522