Version 5.4
Mus musculus Gene: Lefty1
Summary
InnateDB Gene IDBG-207372.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lefty1
Gene Name left right determination factor 1
Synonyms AI450052; Ebaf; Leftb; lefty; lefty-1; Stra3; Tgfb4
Species Mus musculus
Ensembl Gene ENSMUSG00000038793
Encoded Proteins
IDBP-207374
left right determination factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 1:180935022-180938400
Strand Forward strand
Band H4
Transcripts
ENSMUST00000037361 ENSMUSP00000041427
ENSMUST00000132087
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 1 [view]
Protein-DNA 10 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005160 transforming growth factor beta receptor binding
GO:0008083 growth factor activity
GO:0038100 nodal binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0003007 heart morphogenesis
GO:0007368 determination of left/right symmetry
GO:0008285 negative regulation of cell proliferation
GO:0009948 anterior/posterior axis specification
GO:0016049 cell growth
GO:0032526 response to retinoic acid
GO:0040007 growth
GO:0042074 cell migration involved in gastrulation
GO:1900108 negative regulation of nodal signaling pathway
GO:1900124 negative regulation of nodal receptor complex assembly
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_230203
Platelet degranulation pathway
REACT_224553
Hemostasis pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_220645
Signaling by NODAL pathway
REACT_199125
Regulation of signaling by NODAL pathway
REACT_188576
Developmental Biology pathway
REACT_206166
Response to elevated platelet cytosolic Ca2+ pathway
KEGG
mmu04350
TGF-beta signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.378911
RefSeq NM_010094
OMIM
CCDS CCDS15577
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca