InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lefty1

Summary

InnateDB Protein

IDBP-207374.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lefty1

Protein Name

left right determination factor 1

Synonyms

AI450052; Ebaf; Leftb; lefty; lefty-1; Stra3; Tgfb4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000041427

InnateDB Gene

IDBG-207372 (Lefty1)

Protein Structure

UniProt Annotation

Function

Required for left-right axis determination as a regulator of LEFTY2 and NODAL. {ECO:0000269PubMed:9708731}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	1 [view]
Protein-DNA	10 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005160	transforming growth factor beta receptor binding
GO:0008083	growth factor activity
GO:0038100	nodal binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0003007	heart morphogenesis
GO:0007368	determination of left/right symmetry
GO:0008285	negative regulation of cell proliferation
GO:0009948	anterior/posterior axis specification
GO:0016049	cell growth
GO:0032526	response to retinoic acid
GO:0040007	growth
GO:0042074	cell migration involved in gastrulation
GO:1900108	negative regulation of nodal signaling pathway
GO:1900124	negative regulation of nodal receptor complex assembly

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space

Protein Structure and Domains

PDB ID

MGI:107405

InterPro

IPR001111 Transforming growth factor-beta, N-terminal
IPR001839 Transforming growth factor-beta, C-terminal
IPR003942 Left- Right determination factor
IPR029034 Cystine-knot cytokine

PFAM

PF00688
PF00019

PRINTS

PR01427

PIRSF

PIRSF037402

SMART

SM00204

TIGRFAMs

Post-translational Modifications

Modification

Cross-References