Version 5.4
Mus musculus Gene: Rnf43
Summary
InnateDB Gene IDBG-207578.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rnf43
Gene Name ring finger protein 43
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000034177
Encoded Proteins
IDBP-207580
ring finger protein 43
IDBP-207584
ring finger protein 43
IDBP-400097
ring finger protein 43
IDBP-620671
ring finger protein 43
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108375:
RNF43 is a HAP95 (AKAP8L; MIM 609475) binding ubiquitin ligase that promotes cell growth and is upregulated in colon cancer (Yagyu et al., 2004 [PubMed 15492824]; Sugiura et al., 2008 [PubMed 18313049]).[supplied by OMIM, Dec 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:87662722-87735539
Strand Forward strand
Band C
Transcripts
ENSMUST00000092800 ENSMUSP00000090476
ENSMUST00000040089 ENSMUSP00000044241
ENSMUST00000121782 ENSMUSP00000112748
ENSMUST00000134684
ENSMUST00000123658
ENSMUST00000162740
ENSMUST00000124625
ENSMUST00000150866
ENSMUST00000165679 ENSMUSP00000130685
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0004871 signal transducer activity
GO:0005109 frizzled binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0007165 signal transduction
GO:0016055 Wnt signaling pathway
GO:0016567 protein ubiquitination
GO:0030178 negative regulation of Wnt signaling pathway
GO:0038018 Wnt receptor catabolic process
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0072089 stem cell proliferation
Cellular Component
GO:0005635 nuclear envelope
GO:0005789 endoplasmic reticulum membrane
GO:0005887 integral component of plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000108375
View Gene Order
ENSBTAG00000020119
Not yet available
Pathways
NETPATH
REACTOME
REACT_189085
Disease pathway
REACT_214014
Signaling by Wnt pathway
REACT_233046
Signaling by WNT in cancer pathway
REACT_213035
regulation of FZD by ubiquitination pathway
REACT_262115
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_241644
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_207044
TCF dependent signaling in response to WNT pathway
REACT_188257
Signal Transduction pathway
REACT_241402
XAV939 inhibits tankyrase, stabilizing AXIN pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_11045
Signaling by Wnt pathway
REACT_111102
Signal Transduction pathway
REACT_200716
regulation of FZD by ubiquitination pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_116125
Disease pathway
KEGG
INOH
PID NCI
p73pathway
p73 transcription factor network
Cross-References
SwissProt Q5NCP0
TrEMBL A3KMI3
UniProt Splice Variant
Entrez Gene 207742
UniGene Mm.440230
RefSeq XM_006532701 XM_006536449 NM_172448
OMIM
CCDS CCDS25215
HPRD
IMGT
MGI ID MGI:2442609
MGI Symbol Rnf43
EMBL AK028750 AK032782 AL596086 AL604022 BC029717 BC075707 BC131957 CU393486
GenPept AAH29717 AAH75707 AAI31958 BAC26097 BAC28018 CAI35141 CAI35962 CAQ52071
RNA Seq Atlas 207742

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca