InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Lbr

Summary

InnateDB Gene

IDBG-207585.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lbr

Gene Name

lamin B receptor

Synonyms

AI505894; ic

Species

Mus musculus

Ensembl Gene

ENSMUSG00000004880

Encoded Proteins

IDBP-207587

lamin B receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143815:
The protein encoded by this gene belongs to the ERG4/ERG24 family. It localized in the nuclear envelope inner membrane and anchors the lamina and the heterochromatin to the membrane. It may mediate interaction between chromatin and lamin B. Mutations of this gene has been associated with autosomal recessive HEM/Greenberg skeletal dysplasia. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:181815316-181842401

Strand

Reverse strand

Band

Transcripts

ENSMUST00000005003

ENSMUSP00000005003

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
GO:0044822	poly(A) RNA binding
GO:0070087	chromo shadow domain binding

Biological Process

GO:0055114

oxidation-reduction process

Cellular Component

GO:0005635	nuclear envelope
GO:0005637	nuclear inner membrane
GO:0005652	nuclear lamina
GO:0005739	mitochondrion
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031965	nuclear membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000143815

View Gene Order

ENSBTAG00000008453

Not yet available

Pathways

NETPATH

REACTOME

REACT_188937

Metabolism pathway

REACT_232291

Metabolism of lipids and lipoproteins pathway

REACT_208531

Cholesterol biosynthesis pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_9405

Cholesterol biosynthesis pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_111217

Metabolism pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q3U9G9

TrEMBL

Q811V7

UniProt Splice Variant

Entrez Gene

98386

UniGene

Mm.422195

RefSeq

NM_133815 XM_006497070 XM_006497071

OMIM

CCDS

CCDS15584

HPRD

IMGT

MGI ID

MGI:2138281

MGI Symbol

Lbr

EMBL

AK028426 AK030606 AK033459 AK151798 AK161762 AK166850 AK167157 AY148158 AY148159 BC010261 BC014835 BC021516 BC029171 BC042522

GenPept

AAH10261 AAH14835 AAH21516 AAH29171 AAH42522 AAN76314 AAN76315 AAN76316 BAC27042 BAE20442 BAE20487 BAE30698 BAE36563 BAE39069 BAE39298

RNA Seq Atlas

98386