InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lbr

Summary

InnateDB Protein

IDBP-207587.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lbr

Protein Name

lamin B receptor

Synonyms

AI505894; ic;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000005003

InnateDB Gene

IDBG-207585 (Lbr)

Protein Structure

UniProt Annotation

Function

Anchors the lamina and the heterochromatin to the inner nuclear membrane. {ECO:0000250}.

Subcellular Localization

Nucleus inner membrane {ECO:0000250}; Multi- pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
GO:0044822	poly(A) RNA binding
GO:0070087	chromo shadow domain binding

Biological Process

GO:0055114

oxidation-reduction process

Cellular Component

GO:0005635	nuclear envelope
GO:0005637	nuclear inner membrane
GO:0005652	nuclear lamina
GO:0005739	mitochondrion
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031965	nuclear membrane

Protein Structure and Domains

PDB ID

MGI:2138281

InterPro

IPR001171 Ergosterol biosynthesis ERG4/ERG24
IPR002999 Tudor domain
IPR010721 Protein of unknown function DUF1295
IPR019023 Lamin-B receptor of TUDOR domain

PFAM

PF01222
PF00567
PF06966
PF09465

PRINTS

PIRSF

SMART

SM00333

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3U9G9