InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mkks

Summary

InnateDB Gene

IDBG-207925.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mkks

Gene Name

McKusick-Kaufman syndrome

Synonyms

1300013E18Rik; AI463362; AI957237; Bbs6

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027274

Encoded Proteins

IDBP-207927

McKusick-Kaufman syndrome protein

IDBP-261015

McKusick-Kaufman syndrome protein

IDBP-539540

McKusick-Kaufman syndrome protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein which shares sequence similarity with other members of the type II chaperonin family. The encoded protein is a centrosome-shuttling protein and plays an important role in cytokinesis. This protein also interacts with other type II chaperonin members to form a complex known as the BBSome, which involves ciliary membrane biogenesis. This protein is encoded by a downstream open reading frame (dORF). Several upstream open reading frames (uORFs) have been identified, which repress the translation of the dORF, and two of which can encode small mitochondrial membrane proteins. Alternatively spliced transcripts encoding distinct isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:136873780-136891389

Strand

Reverse strand

Band

Transcripts

ENSMUST00000028730	ENSMUSP00000028730
ENSMUST00000110089	ENSMUSP00000105716
ENSMUST00000144275	ENSMUSP00000121494

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001103	RNA polymerase II repressing transcription factor binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0051082	unfolded protein binding

Biological Process

GO:0006457	protein folding
GO:0007286	spermatid development
GO:0007608	sensory perception of smell
GO:0010629	negative regulation of gene expression
GO:0014824	artery smooth muscle contraction
GO:0021756	striatum development
GO:0021766	hippocampus development
GO:0021987	cerebral cortex development
GO:0033210	leptin-mediated signaling pathway
GO:0035058	nonmotile primary cilium assembly
GO:0035176	social behavior
GO:0038108	negative regulation of appetite by leptin-mediated signaling pathway
GO:0040018	positive regulation of multicellular organism growth
GO:0042311	vasodilation
GO:0042384	cilium assembly
GO:0044267	cellular protein metabolic process
GO:0044321	response to leptin
GO:0045444	fat cell differentiation
GO:0045494	photoreceptor cell maintenance
GO:0045776	negative regulation of blood pressure
GO:0048854	brain morphogenesis
GO:0050910	detection of mechanical stimulus involved in sensory perception of sound
GO:0051131	chaperone-mediated protein complex assembly
GO:0051216	cartilage development
GO:0060271	cilium morphogenesis
GO:0060296	regulation of cilium beat frequency involved in ciliary motility

Cellular Component

GO:0005622	intracellular
GO:0005813	centrosome
GO:0005829	cytosol
GO:0031514	motile cilium

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000125863

View Gene Order

ENSBTAG00000034987

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.272570 Mm.448991

RefSeq

NM_001141946 NM_021527 XM_006499970

OMIM

CCDS

CCDS16794

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas