InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Trim25

Summary

InnateDB Gene

IDBG-208127.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trim25

Gene Name

tripartite motif-containing 25

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000000275

Encoded Proteins

IDBP-208129

tripartite motif-containing 25

IDBP-208131

tripartite motif-containing 25

IDBP-265696

tripartite motif-containing 25

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 17392790

[Homo sapiens] TRIM25 is essential for RIG-I-mediated antiviral activity by inducing Lys 63-linked ubiquitination of DDX58 which is crucial for RIG-I signalling pathway.

PMID 23438823

[Homo sapiens] TRIM25 was identified in a systematic screen for positive regulators of innate immune responses.

PMID 23950712

[Homo sapiens] RNF135 is essential for the association of DDX58 (RIG-I) and TRIM25, resulting in the activation of RIG-I signalling.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000121060:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivation domains suggests that this protein may act as a transcription factor, similar to several other members of the TRIM family. Expression of the gene is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast cancer as a primary response gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:88999376-89020293

Strand

Forward strand

Band

Transcripts

ENSMUST00000100627	ENSMUSP00000098192
ENSMUST00000000284	ENSMUSP00000000284
ENSMUST00000107896	ENSMUSP00000103528

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	22 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016881	acid-amino acid ligase activity
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0016567	protein ubiquitination
GO:0033280	response to vitamin D
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043627	response to estrogen
GO:0045087	innate immune response
GO:0046596	regulation of viral entry into host cell
GO:0046597	negative regulation of viral entry into host cell
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051607	defense response to virus
GO:1902186	regulation of viral release from host cell
GO:1902187	negative regulation of viral release from host cell