InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TRIM25

Summary

InnateDB Gene

IDBG-60223.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIM25

Gene Name

tripartite motif containing 25

Synonyms

EFP; RNF147; Z147; ZNF147

Species

Homo sapiens

Ensembl Gene

ENSG00000121060

Encoded Proteins

IDBP-60225

tripartite motif containing 25

IDBP-598338

tripartite motif containing 25

IDBP-759240

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 17392790

TRIM25 is essential for RIG-I-mediated antiviral activity by inducing Lys 63-linked ubiquitination of DDX58 which is crucial for RIG-I signalling pathway.

PMID 23438823

TRIM25 was identified in a systematic screen for positive regulators of innate immune responses.

PMID 23950712

RNF135 is essential for the association of DDX58 (RIG-I) and TRIM25, resulting in the activation of RIG-I signalling.

Entrez Gene

Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivation domains suggests that this protein may act as a transcription factor, similar to several other members of the TRIM family. Expression of the gene is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast cancer as a primary response gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:56887909-56914038

Strand

Reverse strand

Band

q22

Transcripts

ENST00000316881	ENSP00000323889
ENST00000537230	ENSP00000445961
ENST00000574997
ENST00000572550
ENST00000574234
ENST00000573108
ENST00000572021	ENSP00000459980
ENST00000570473
ENST00000570749

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 74 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	74 [view]
Protein-Protein	69 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016881	acid-amino acid ligase activity
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0016032	viral process
GO:0016567	protein ubiquitination
GO:0032480	negative regulation of type I interferon production
GO:0033280	response to vitamin D
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043627	response to estrogen
GO:0045087	innate immune response (InnateDB)
GO:0046596	regulation of viral entry into host cell
GO:0046597	negative regulation of viral entry into host cell
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051607	defense response to virus
GO:1902186	regulation of viral release from host cell
GO:1902187	negative regulation of viral release from host cell