InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cenpf

Summary

InnateDB Gene

IDBG-208396.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cenpf

Gene Name

centromere protein F

Synonyms

6530404A22Rik; AI325968; CENF; Lek1; mitosin; PRO1779

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026605

Encoded Proteins

IDBP-626771

centromere protein F

IDBP-626772

centromere protein F

IDBP-626773

centromere protein F

IDBP-626775

centromere protein F

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000117724:
This gene encodes a protein that associates with the centromere-kinetochore complex. The protein is a component of the nuclear matrix during the G2 phase of interphase. In late G2 the protein associates with the kinetochore and maintains this association through early anaphase. It localizes to the spindle midzone and the intracellular bridge in late anaphase and telophase, respectively, and is thought to be subsequently degraded. The localization of this protein suggests that it may play a role in chromosome segregation during mitotis. It is thought to form either a homodimer or heterodimer. Autoantibodies against this protein have been found in patients with cancer or graft versus host disease. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:189640599-189688086

Strand

Reverse strand

Band

Transcripts

ENSMUST00000171929	ENSMUSP00000129738
ENSMUST00000165798	ENSMUSP00000132430
ENSMUST00000165962	ENSMUSP00000132759
ENSMUST00000165663	ENSMUSP00000130308

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0008134	transcription factor binding
GO:0042803	protein homodimerization activity
GO:0045502	dynein binding

Biological Process

GO:0000085	mitotic G2 phase
GO:0000087	mitotic M phase
GO:0000278	mitotic cell cycle
GO:0007059	chromosome segregation
GO:0010389	regulation of G2/M transition of mitotic cell cycle
GO:0015031	protein transport
GO:0016202	regulation of striated muscle tissue development
GO:0045892	negative regulation of transcription, DNA-templated
GO:0051310	metaphase plate congression

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000776	kinetochore
GO:0000922	spindle pole
GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005737	cytoplasm
GO:0005819	spindle
GO:0016363	nuclear matrix
GO:0030496	midbody
GO:0045120	pronucleus