InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cenpf

Summary

InnateDB Protein

IDBP-626771.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cenpf

Protein Name

centromere protein F

Synonyms

6530404A22Rik; AI325968; CENF; Lek1; mitosin; PRO1779;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000129738

InnateDB Gene

IDBG-208396 (Cenpf)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0008134	transcription factor binding
GO:0042803	protein homodimerization activity
GO:0045502	dynein binding

Biological Process

GO:0000085	mitotic G2 phase
GO:0000087	mitotic M phase
GO:0000278	mitotic cell cycle
GO:0007059	chromosome segregation
GO:0010389	regulation of G2/M transition of mitotic cell cycle
GO:0015031	protein transport
GO:0016202	regulation of striated muscle tissue development
GO:0045892	negative regulation of transcription, DNA-templated
GO:0051310	metaphase plate congression

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000776	kinetochore
GO:0000922	spindle pole
GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005737	cytoplasm
GO:0005819	spindle
GO:0016363	nuclear matrix
GO:0030496	midbody
GO:0045120	pronucleus

Protein Structure and Domains

PDB ID

MGI:1313302

InterPro

IPR009020 Proteinase inhibitor, propeptide
IPR009053 Prefoldin
IPR010310 Type VII secretion system ESAT-6-like
IPR018302 Kinetochore protein Cenp-F/LEK1, Rb protein-binding domain
IPR018463 Centromere protein Cenp-F, N-terminal
IPR019513 Centromere protein Cenp-F, leucine-rich repeat-containing domain

PFAM

PF06013
PF10490
PF10481
PF10473

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-