Version 5.4
Homo sapiens Gene: FUT3
Summary
InnateDB Gene IDBG-20884.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FUT3
Gene Name fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
Synonyms CD174; FT3B; FucT-III; LE; Les
Species Homo sapiens
Ensembl Gene ENSG00000171124
Encoded Proteins
IDBP-20886
fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
IDBP-366723
fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
IDBP-763636
IDBP-762857
IDBP-764867
IDBP-765305
IDBP-765621
IDBP-761510
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:5842888-5851474
Strand Reverse strand
Band p13.3
Transcripts
ENST00000303225 ENSP00000305603
ENST00000458379 ENSP00000416443
ENST00000587183 ENSP00000468795
ENST00000589918 ENSP00000468123
ENST00000588539
ENST00000593144
ENST00000589620 ENSP00000465804
ENST00000585715 ENSP00000467633
ENST00000587048 ENSP00000468515
ENST00000589714 ENSP00000467081
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008417 fucosyltransferase activity
GO:0017060 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity
GO:0046920 alpha-(1->3)-fucosyltransferase activity
Biological Process
GO:0006486 protein glycosylation
GO:0009312 oligosaccharide biosynthetic process
GO:0009988 cell-cell recognition
GO:0036065 fucosylation
GO:0043413 macromolecule glycosylation
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0032580 Golgi cisterna membrane
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
hsa00601
Glycosphingolipid biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.169238
RefSeq NM_000149 NM_001097639 NM_001097640 NM_001097641
HUGO
OMIM
CCDS CCDS12153
HPRD 00196
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca