InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FUT3

Summary

InnateDB Protein

IDBP-366723.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FUT3

Protein Name

fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)

Synonyms

CD174; FT3B; FucT-III; LE; Les;

Species

Homo sapiens

Ensembl Protein

ENSP00000416443

InnateDB Gene

IDBG-20884 (FUT3)

Protein Structure

UniProt Annotation

Function

May catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of Vim-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination; Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an inactive enzyme. Also acts on the corresponding 1,4-galactosyl derivative, forming 1,3-L-fucosyl links.

Subcellular Localization

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.

Disease Associations

Tissue Specificity

Highly expressed in stomach, colon, small intestine, lung and kidney and to a lesser extent in salivary gland, bladder, uterus and liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008417	fucosyltransferase activity
GO:0017060	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity
GO:0046920	alpha-(1->3)-fucosyltransferase activity

Biological Process

GO:0006486	protein glycosylation
GO:0009312	oligosaccharide biosynthetic process
GO:0009988	cell-cell recognition
GO:0036065	fucosylation
GO:0043413	macromolecule glycosylation