Version 5.4
Mus musculus Gene: Cacna1g
Summary
InnateDB Gene IDBG-208893.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cacna1g
Gene Name calcium channel, voltage-dependent, T type, alpha 1G subunit
Synonyms [a]1G; a1G; alpha-1G; Cav3.1d; mKIAA1123
Species Mus musculus
Ensembl Gene ENSMUSG00000020866
Encoded Proteins
IDBP-208895
calcium channel, voltage-dependent, T type, alpha 1G subunit
IDBP-208897
calcium channel, voltage-dependent, T type, alpha 1G subunit
IDBP-208903
calcium channel, voltage-dependent, T type, alpha 1G subunit
IDBP-265894
calcium channel, voltage-dependent, T type, alpha 1G subunit
IDBP-265896
calcium channel, voltage-dependent, T type, alpha 1G subunit
IDBP-265898
calcium channel, voltage-dependent, T type, alpha 1G subunit
IDBP-265900
calcium channel, voltage-dependent, T type, alpha 1G subunit
IDBP-265902
calcium channel, voltage-dependent, T type, alpha 1G subunit
IDBP-265904
calcium channel, voltage-dependent, T type, alpha 1G subunit
IDBP-265906
calcium channel, voltage-dependent, T type, alpha 1G subunit
IDBP-265908
calcium channel, voltage-dependent, T type, alpha 1G subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000006283:
Voltage-sensitive calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death. This gene encodes a T-type, low-voltage activated calcium channel. The T-type channels generate currents that are both transient, owing to fast inactivation, and tiny, owing to small conductance. T-type channels are thought to be involved in pacemaker activity, low-threshold calcium spikes, neuronal oscillations and resonance, and rebound burst firing. Many alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:94408391-94474198
Strand Reverse strand
Band D
Transcripts
ENSMUST00000021234 ENSMUSP00000021234
ENSMUST00000103166 ENSMUSP00000099455
ENSMUST00000100561 ENSMUSP00000098127
ENSMUST00000107793 ENSMUSP00000103422
ENSMUST00000107792 ENSMUSP00000103421
ENSMUST00000107791 ENSMUSP00000103420
ENSMUST00000107790 ENSMUSP00000103419
ENSMUST00000107789 ENSMUSP00000103418
ENSMUST00000107788 ENSMUSP00000103417
ENSMUST00000107786 ENSMUSP00000103415
ENSMUST00000107785 ENSMUSP00000103414
ENSMUST00000133331
ENSMUST00000146160
ENSMUST00000142190
ENSMUST00000133000
ENSMUST00000152811
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005245 voltage-gated calcium channel activity
GO:0005515 protein binding
GO:0008332 low voltage-gated calcium channel activity
GO:0097110 scaffold protein binding
Biological Process
GO:0001508 action potential
GO:0002027 regulation of heart rate
GO:0006811 ion transport
GO:0007268 synaptic transmission
GO:0010045 response to nickel cation
GO:0034765 regulation of ion transmembrane transport
GO:0042391 regulation of membrane potential
GO:0045956 positive regulation of calcium ion-dependent exocytosis
GO:0055085 transmembrane transport
GO:0060371 regulation of atrial cardiac muscle cell membrane depolarization
GO:0070509 calcium ion import
GO:0086010 membrane depolarization during action potential
Cellular Component
GO:0005886 plasma membrane
GO:0005891 voltage-gated calcium channel complex
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000006283
View Gene Order
ENSBTAG00000009835
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04930
Type II diabetes mellitus pathway
mmu04020
Calcium signaling pathway pathway
mmu04010
MAPK signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_18312
NCAM1 interactions pathway
REACT_18334
NCAM signaling for neurite out-growth pathway
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
KEGG
hsa04010
MAPK signaling pathway pathway
hsa04930
Type II diabetes mellitus pathway
hsa04020
Calcium signaling pathway pathway
INOH
PID NCI
betacatenin_nuc_pathway
Regulation of nuclear beta catenin signaling and target gene transcription
Cross-References
SwissProt
TrEMBL Q5SUF6 Q6ZPX4
UniProt Splice Variant
Entrez Gene 12291
UniGene Mm.29585 Mm.411330
RefSeq XM_006532084 NM_001112813 NM_001177888 NM_001177890 NM_009783 XM_006532069 XM_006532070 XM_006532085 XM_006532086 XM_006532087 XM_006532088
OMIM
CCDS CCDS25255 CCDS48884 CCDS48885 CCDS48886
HPRD
IMGT
MGI ID MGI:1201678
MGI Symbol Cacna1g
EMBL AK129294 AL645965
GenPept BAC98104
RNA Seq Atlas 12291

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca