InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pax1

Summary

InnateDB Gene

IDBG-208918.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pax1

Gene Name

paired box gene 1

Synonyms

hbs; hunchback; Pax-1; un; undulated; wt

Species

Mus musculus

Ensembl Gene

ENSMUSG00000037034

Encoded Proteins

IDBP-261265

paired box gene 1

IDBP-541169

paired box gene 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125813:
This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. This gene plays a role in pattern formation during embryogenesis and may be essential for development of the vertebral column. This gene is silenced by methylation in ovarian and cervical cancers and may be a tumor suppressor gene. Mutations in this gene are also associated with vertebral malformations. [provided by RefSeq, Mar 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:147361925-147393295

Strand

Forward strand

Band

Transcripts

ENSMUST00000109968	ENSMUSP00000105594
ENSMUST00000126068	ENSMUSP00000119667
ENSMUST00000156584

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity

Biological Process

GO:0001501	skeletal system development
GO:0001756	somitogenesis
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007389	pattern specification process
GO:0008283	cell proliferation
GO:0009887	organ morphogenesis
GO:0043367	CD4-positive, alpha-beta T cell differentiation
GO:0043374	CD8-positive, alpha-beta T cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048538	thymus development
GO:0060017	parathyroid gland development
GO:0060349	bone morphogenesis
GO:0061056	sclerotome development

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000125813

View Gene Order

ENSBTAG00000006742

Not yet available

Cross-References

SwissProt

P09084

TrEMBL

Q548R5 Q8K4Q1 Q8K4Q2

UniProt Splice Variant

Entrez Gene

18503

UniGene

Mm.315502 Mm.483524

RefSeq

NM_008780 XM_006498911 XM_006498912

OMIM

CCDS

CCDS16835

HPRD

IMGT

MGI ID

MGI:97485

MGI Symbol

Pax1

EMBL

AB080656 AB080657 AF285175 AJ133503 AJ133504 AJ133505 AL805918 BC140989 CH466519 M20978 M69222

GenPept

AAA37793 AAA39888 AAI40990 AAK01146 BAC10687 BAC10688 CAB38370 CAM17060 EDL28525

RNA Seq Atlas

18503