InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pax1

Summary

InnateDB Protein

IDBP-261265.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pax1

Protein Name

paired box gene 1

Synonyms

hbs; hunchback; Pax-1; un; undulated; wt;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000105594

InnateDB Gene

IDBG-208918 (Pax1)

Protein Structure

UniProt Annotation

Function

This protein is a transcriptional activator. It may play a role in the formation of segmented structures of the embryo. May play an important role in the normal development of the vertebral column.

Subcellular Localization

Nucleus.

Disease Associations

Note=Undulated (un) homozygous mice exhibits vertebral malformations along the entire rostro-caudal axis. This is due to a single mutation in the paired box region.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity

Biological Process

GO:0001501	skeletal system development
GO:0001756	somitogenesis
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007389	pattern specification process
GO:0008283	cell proliferation
GO:0009887	organ morphogenesis
GO:0043367	CD4-positive, alpha-beta T cell differentiation
GO:0043374	CD8-positive, alpha-beta T cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048538	thymus development
GO:0060017	parathyroid gland development
GO:0060349	bone morphogenesis
GO:0061056	sclerotome development