InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Foxa2

Summary

InnateDB Gene

IDBG-208945.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Foxa2

Gene Name

forkhead box A2

Synonyms

Hnf-3b; HNF3-beta; Hnf3b; HNF3beta; Tcf-3b; Tcf3b

Species

Mus musculus

Ensembl Gene

ENSMUSG00000037025

Encoded Proteins

IDBP-208947

forkhead box A2

IDBP-261271

forkhead box A2

IDBP-621675

forkhead box A2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20483781

Foxa2 is expressed selectively in the respiratory epithelium where it plays a critical role in regulating genetic programs influencing Th2 cell-mediated pulmonary inflammation.

InnateDB Annotation from Orthologs

Summary

PMID 20483781

[Homo sapiens] FOXA2 is expressed selectively in the respiratory epithelium where it plays a critical role in regulating genetic programs influencing Th2 cell-mediated pulmonary inflammation.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125798:
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:148042877-148046969

Strand

Reverse strand

Band

Transcripts

ENSMUST00000047315	ENSMUSP00000045918
ENSMUST00000109964	ENSMUSP00000105590
ENSMUST00000146242
ENSMUST00000172928	ENSMUSP00000134081

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	5 [view]
Protein-DNA	14 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001205	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008301	DNA binding, bending
GO:0019904	protein domain specific binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0000432	positive regulation of transcription from RNA polymerase II promoter by glucose
GO:0000433	negative regulation of transcription from RNA polymerase II promoter by glucose
GO:0001701	in utero embryonic development
GO:0001705	ectoderm formation
GO:0001708	cell fate specification
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007389	pattern specification process
GO:0008344	adult locomotory behavior
GO:0009653	anatomical structure morphogenesis
GO:0009952	anterior/posterior pattern specification
GO:0009953	dorsal/ventral pattern formation
GO:0010468	regulation of gene expression
GO:0010719	negative regulation of epithelial to mesenchymal transition
GO:0016568	chromatin modification
GO:0019216	regulation of lipid metabolic process
GO:0019218	regulation of steroid metabolic process
GO:0021533	cell differentiation in hindbrain
GO:0021904	dorsal/ventral neural tube patterning
GO:0023019	signal transduction involved in regulation of gene expression
GO:0030193	regulation of blood coagulation
GO:0030324	lung development
GO:0031018	endocrine pancreas development
GO:0032525	somite rostral/caudal axis specification
GO:0033132	negative regulation of glucokinase activity
GO:0040019	positive regulation of embryonic development
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045087	innate immune response (InnateDB)
GO:0045665	negative regulation of neuron differentiation
GO:0045666	positive regulation of neuron differentiation
GO:0045880	positive regulation of smoothened signaling pathway
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0045945	positive regulation of transcription from RNA polymerase III promoter
GO:0048468	cell development
GO:0048646	anatomical structure formation involved in morphogenesis
GO:0048665	neuron fate specification
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity
GO:0060441	epithelial tube branching involved in lung morphogenesis
GO:0060487	lung epithelial cell differentiation
GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0061448	connective tissue development
GO:0070741	response to interleukin-6
GO:0071542	dopaminergic neuron differentiation
GO:0090009	primitive streak formation
GO:2000543	positive regulation of gastrulation
GO:2000971	negative regulation of detection of glucose
GO:2000976	regulation of transcription from RNA polymerase II promoter involved in detection of glucose