InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Foxa2

Summary

InnateDB Protein

IDBP-261271.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Foxa2

Protein Name

forkhead box A2

Synonyms

Hnf-3b; HNF3-beta; Hnf3b; HNF3beta; Tcf-3b; Tcf3b;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000105590

InnateDB Gene

IDBG-208945 (Foxa2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	5 [view]
Protein-DNA	14 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001205	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008301	DNA binding, bending
GO:0019904	protein domain specific binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000432	positive regulation of transcription from RNA polymerase II promoter by glucose
GO:0000433	negative regulation of transcription from RNA polymerase II promoter by glucose
GO:0001701	in utero embryonic development
GO:0001705	ectoderm formation
GO:0001708	cell fate specification
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007389	pattern specification process
GO:0008344	adult locomotory behavior
GO:0009653	anatomical structure morphogenesis
GO:0009952	anterior/posterior pattern specification
GO:0009953	dorsal/ventral pattern formation
GO:0010468	regulation of gene expression
GO:0010719	negative regulation of epithelial to mesenchymal transition
GO:0016568	chromatin modification
GO:0019216	regulation of lipid metabolic process
GO:0019218	regulation of steroid metabolic process
GO:0021533	cell differentiation in hindbrain
GO:0021904	dorsal/ventral neural tube patterning
GO:0023019	signal transduction involved in regulation of gene expression
GO:0030193	regulation of blood coagulation
GO:0030324	lung development
GO:0031018	endocrine pancreas development
GO:0032525	somite rostral/caudal axis specification
GO:0033132	negative regulation of glucokinase activity
GO:0040019	positive regulation of embryonic development
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045087	innate immune response (InnateDB)
GO:0045665	negative regulation of neuron differentiation
GO:0045666	positive regulation of neuron differentiation
GO:0045880	positive regulation of smoothened signaling pathway
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0045945	positive regulation of transcription from RNA polymerase III promoter
GO:0048468	cell development
GO:0048646	anatomical structure formation involved in morphogenesis
GO:0048665	neuron fate specification
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity
GO:0060441	epithelial tube branching involved in lung morphogenesis
GO:0060487	lung epithelial cell differentiation
GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0061448	connective tissue development
GO:0070741	response to interleukin-6
GO:0071542	dopaminergic neuron differentiation
GO:0090009	primitive streak formation
GO:2000543	positive regulation of gastrulation
GO:2000971	negative regulation of detection of glucose
GO:2000976	regulation of transcription from RNA polymerase II promoter involved in detection of glucose