InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pdk2

Summary

InnateDB Gene

IDBG-209439.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pdk2

Gene Name

pyruvate dehydrogenase kinase, isoenzyme 2

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000038967

Encoded Proteins

IDBP-209441

pyruvate dehydrogenase kinase, isoenzyme 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000005882:
This gene encodes a member of the pyruvate dehydrogenase kinase family. The encoded protein phosphorylates pyruvate dehydrogenase, down-regulating the activity of the mitochondrial pyruvate dehydrogenase complex. Overexpression of this gene may play a role in both cancer and diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:95026258-95041354

Strand

Reverse strand

Band

Transcripts

ENSMUST00000038431	ENSMUSP00000041447
ENSMUST00000126730
ENSMUST00000129262
ENSMUST00000141712
ENSMUST00000155857

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004674	protein serine/threonine kinase activity
GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006006	glucose metabolic process
GO:0006111	regulation of gluconeogenesis
GO:0006468	protein phosphorylation
GO:0006885	regulation of pH
GO:0008286	insulin receptor signaling pathway
GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate
GO:0010565	regulation of cellular ketone metabolic process
GO:0010906	regulation of glucose metabolic process
GO:0031670	cellular response to nutrient
GO:0034614	cellular response to reactive oxygen species
GO:0042593	glucose homeostasis
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator