Version 5.4
Homo sapiens Gene: PDK2
Summary
InnateDB Gene IDBG-58067.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDK2
Gene Name pyruvate dehydrogenase kinase, isozyme 2
Synonyms PDHK2; PDKII
Species Homo sapiens
Ensembl Gene ENSG00000005882
Encoded Proteins
IDBP-58069
pyruvate dehydrogenase kinase, isozyme 2
IDBP-476113
pyruvate dehydrogenase kinase, isozyme 2
IDBP-478524
pyruvate dehydrogenase kinase, isozyme 2
IDBP-481237
pyruvate dehydrogenase kinase, isozyme 2
IDBP-473548
pyruvate dehydrogenase kinase, isozyme 2
IDBP-473618
pyruvate dehydrogenase kinase, isozyme 2
IDBP-484711
pyruvate dehydrogenase kinase, isozyme 2
IDBP-806808
pyruvate dehydrogenase kinase, isozyme 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the pyruvate dehydrogenase kinase family. The encoded protein phosphorylates pyruvate dehydrogenase, down-regulating the activity of the mitochondrial pyruvate dehydrogenase complex. Overexpression of this gene may play a role in both cancer and diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:50094737-50112152
Strand Forward strand
Band q21.33
Transcripts
ENST00000007708 ENSP00000007708
ENST00000508030 ENSP00000427682
ENST00000503176 ENSP00000420927
ENST00000503614 ENSP00000425265
ENST00000508960
ENST00000505897
ENST00000505440 ENSP00000425615
ENST00000511026
ENST00000512238 ENSP00000421178
ENST00000515040
ENST00000510219 ENSP00000423310
ENST00000506242
ENST00000503076
ENST00000512204
ENST00000506647
ENST00000614357 ENSP00000481915
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 5 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006006 glucose metabolic process
GO:0006090 pyruvate metabolic process
GO:0006111 regulation of gluconeogenesis
GO:0006468 protein phosphorylation
GO:0006885 regulation of pH
GO:0008286 insulin receptor signaling pathway
GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate
GO:0010565 regulation of cellular ketone metabolic process
GO:0010906 regulation of glucose metabolic process
GO:0031670 cellular response to nutrient
GO:0034614 cellular response to reactive oxygen species
GO:0042593 glucose homeostasis
GO:0044237 cellular metabolic process
GO:0044281 small molecule metabolic process
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005967 mitochondrial pyruvate dehydrogenase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038967
View Gene Order
ENSBTAG00000008744
Not yet available
Pathways
NETPATH
REACTOME
REACT_12528
Regulation of pyruvate dehydrogenase (PDH) complex pathway
REACT_2071
Pyruvate metabolism pathway
REACT_1046
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
REACT_111083
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_111217
Metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.256667
RefSeq NM_001199898 NM_001199899 NM_002611
HUGO
OMIM
CCDS CCDS11559 CCDS56039
HPRD 03955
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca