InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Fkbp1a

Summary

InnateDB Gene

IDBG-209494.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fkbp1a

Gene Name

FK506 binding protein 1a

Synonyms

Fkbp; Fkbp1; FKBP12

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032966

Encoded Proteins

IDBP-209496

FK506 binding protein 1a

IDBP-537802

FK506 binding protein 1a

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the immunophilin family. The encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, and is associated with immunoregulation, protein folding, receptor signaling, protein trafficking and T-cell activation. It may modulate the calcium release activity of the ryanodine receptor Ryr1. It also interacts with the type I TGF-beta receptor. Disruption of this gene in mouse causes severe ventricular defects. Pseudogenes of this gene have been defined on chromosomes 4, 10, 14, and 16. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:151542483-151561692

Strand

Forward strand

Band

Transcripts

ENSMUST00000044011	ENSMUSP00000037206
ENSMUST00000142985
ENSMUST00000137597
ENSMUST00000126670
ENSMUST00000148295
ENSMUST00000143230
ENSMUST00000144171
ENSMUST00000148978
ENSMUST00000142271	ENSMUSP00000118725
ENSMUST00000132614

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Experimentally validated
Total	14 [view]
Protein-Protein	13 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003755	peptidyl-prolyl cis-trans isomerase activity
GO:0005160	transforming growth factor beta receptor binding
GO:0005515	protein binding
GO:0005528	FK506 binding
GO:0008144	drug binding
GO:0019899	enzyme binding
GO:0030544	Hsp70 protein binding
GO:0034713	type I transforming growth factor beta receptor binding
GO:0042803	protein homodimerization activity
GO:0044325	ion channel binding

Biological Process

GO:0000413	protein peptidyl-prolyl isomerization
GO:0001933	negative regulation of protein phosphorylation
GO:0003007	heart morphogenesis
GO:0006457	protein folding
GO:0006936	muscle contraction
GO:0010039	response to iron ion
GO:0018208	peptidyl-proline modification
GO:0019221	cytokine-mediated signaling pathway
GO:0031000	response to caffeine
GO:0042098	T cell proliferation
GO:0051209	release of sequestered calcium ion into cytosol
GO:0055010	ventricular cardiac muscle tissue morphogenesis
GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity
GO:0060347	heart trabecula formation

Cellular Component

GO:0005829	cytosol
GO:0016020	membrane
GO:0030424	axon
GO:0033017	sarcoplasmic reticulum membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0043679	axon terminus