InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fkbp1a

Summary

InnateDB Protein

IDBP-209496.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fkbp1a

Protein Name

FK506 binding protein 1a

Synonyms

Fkbp; Fkbp1; FKBP12;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000037206

InnateDB Gene

IDBG-209494 (Fkbp1a)

Protein Structure

UniProt Annotation

Function

Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Experimentally validated
Total	14 [view]
Protein-Protein	13 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003755	peptidyl-prolyl cis-trans isomerase activity
GO:0005160	transforming growth factor beta receptor binding
GO:0005515	protein binding
GO:0005528	FK506 binding
GO:0008144	drug binding
GO:0019899	enzyme binding
GO:0030544	Hsp70 protein binding
GO:0034713	type I transforming growth factor beta receptor binding
GO:0042803	protein homodimerization activity
GO:0044325	ion channel binding

Biological Process

GO:0000413	protein peptidyl-prolyl isomerization
GO:0001933	negative regulation of protein phosphorylation
GO:0003007	heart morphogenesis
GO:0006457	protein folding
GO:0006936	muscle contraction
GO:0010039	response to iron ion
GO:0018208	peptidyl-proline modification
GO:0019221	cytokine-mediated signaling pathway
GO:0031000	response to caffeine
GO:0042098	T cell proliferation
GO:0051209	release of sequestered calcium ion into cytosol
GO:0055010	ventricular cardiac muscle tissue morphogenesis
GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity
GO:0060347	heart trabecula formation

Cellular Component

GO:0005829	cytosol
GO:0016020	membrane
GO:0030424	axon
GO:0033017	sarcoplasmic reticulum membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0043679	axon terminus