Version 5.4
| Homo sapiens Gene: IFNAR1 | |||||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||||
| InnateDB Gene | IDBG-2095.6 | ||||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||
| Gene Symbol | IFNAR1 | ||||||||||||||||||||||||
| Gene Name | interferon (alpha, beta and omega) receptor 1 | ||||||||||||||||||||||||
| Synonyms | AVP; IFN-alpha-REC; IFNAR; IFNBR; IFRC | ||||||||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||||||||
| Ensembl Gene | ENSG00000142166 | ||||||||||||||||||||||||
| Encoded Proteins |
interferon (alpha, beta and omega) receptor 1
interferon (alpha, beta and omega) receptor 1
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| Protein Structure | |||||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||||||||
| Summary |
IFNAR1 acts as a docking site for the latent form of STAT2 and mediates the interaction between JAK kinases and the STAT transcription factors.
IFNAR1 interacts with the amino-terminal half of TYK2 and this interaction is required for interferon (IFN)-alpha signal transduction.
The interferon alpha receptor is composed of two subunits: IFNAR1 and IFNAR2;IL10RB. IFNAR1 binds to STAT2 to initiate interferon (IFN) signalling.
Type I interferons (IFNs) play an important role in innate immunity to protozoan parasites by binding the IFN alpha receptor, composed of IFNAR1 and IFNAR2;IL10RB, and regulating neutrophil/monocyte recruitment, neutrophil turnover, and Leishmania infection.
IFNAR1 deficiency completely abolishes the reduction of sterol biosynthetic activity of macrophages during viral infections, thereby linking the regulation of lipid metabolism pathway with interferon anti-viral defence responses. (Demonstrated in murine model)
IFNAR1 is phosphorylated by p38 MAP kinase in response to pathogen-recognition receptor stimulation. This phosphorylation promotes IFNAR1 ubiquitination and accelerates the proteolytic turnover of the receptor, which leads to attenuation of type I IFN signalling.
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| InnateDB Annotation from Orthologs | |||||||||||||||||||||||||
| Summary |
[Mus musculus] Ifnar1 deficiency completely abolishes the reduction of sterol biosynthetic activity of macrophages during viral infections, thereby linking the regulation of lipid metabolism pathway with interferon anti-viral defence responses.
[Mus musculus] Ifnar1 is phosphorylated by p38 MAP kinase in response to pathogen-recognition receptor stimulation. This phosphorylation promotes Ifnar1 ubiquitination and accelerates the proteolytic turnover of the receptor, which leads to attenuation of type I IFN signalling.
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| Entrez Gene | |||||||||||||||||||||||||
| Summary |
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||||
| Genomic Location | Chromosome 21:33324477-33359862 | ||||||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||||||
| Band | q22.11 | ||||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||||
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Species
Mus musculus
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Gene ID
Gene Order
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| Pathways | |||||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||||
| REACTOME |
Regulation of IFNA signaling pathway
Interferon alpha/beta signaling pathway
Cytokine Signaling in Immune system pathway
Interferon Signaling pathway
Immune System pathway
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| KEGG |
Cytokine-cytokine receptor interaction pathway
Toll-like receptor signaling pathway pathway
Jak-STAT signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
Osteoclast differentiation pathway
Hepatitis C pathway
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| INOH |
JAK STAT pathway and regulation pathway
IFN alpha signaling pathway
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| PID NCI |
Downstream signaling in naïve CD8+ T cells
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| Cross-References | |||||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||||
| UniGene | Hs.529400 Hs.599565 Hs.627081 | ||||||||||||||||||||||||
| RefSeq | NM_000629 XM_005260964 | ||||||||||||||||||||||||
| HUGO | |||||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||||
| CCDS | CCDS13624 | ||||||||||||||||||||||||
| HPRD | 00126 | ||||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||||
| EMBL | |||||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||||||||