InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ifnar1

Summary

InnateDB Gene

IDBG-176038.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ifnar1

Gene Name

interferon (alpha and beta) receptor 1

Synonyms

CD118; Ifar; Ifnar; Ifrc; Infar

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022967

Encoded Proteins

IDBP-176040

interferon (alpha and beta) receptor 1

IDBP-400873

interferon (alpha and beta) receptor 1

IDBP-538950

interferon (alpha and beta) receptor 1

IDBP-535831

interferon (alpha and beta) receptor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21408089

Ifnar1 deficiency completely abolishes the reduction of sterol biosynthetic activity of macrophages during viral infections, thereby linking the regulation of lipid metabolism pathway with interferon anti-viral defence responses.

PMID 21695243

Ifnar1 is phosphorylated by p38 MAP kinase in response to pathogen-recognition receptor stimulation. This phosphorylation promotes Ifnar1 ubiquitination and accelerates the proteolytic turnover of the receptor, which leads to attenuation of type I IFN signalling.

InnateDB Annotation from Orthologs

Summary

PMID 8605876

[Homo sapiens] IFNAR1 acts as a docking site for the latent form of STAT2 and mediates the interaction between JAK kinases and the STAT transcription factors.

PMID 9461596

[Homo sapiens] IFNAR1 interacts with the amino-terminal half of TYK2 and this interaction is required for interferon (IFN)-alpha signal transduction.

PMID 12220192

[Homo sapiens] The interferon alpha receptor is composed of two subunits: IFNAR1 and IFNAR2;IL10RB. IFNAR1 binds to STAT2 to initiate interferon (IFN) signalling.

PMID 20483775

[Homo sapiens] Type I interferons (IFNs) play an important role in innate immunity to protozoan parasites by binding the IFN alpha receptor, composed of IFNAR1 and IFNAR2;IL10RB, and regulating neutrophil/monocyte recruitment, neutrophil turnover, and Leishmania infection.

PMID 21408089

[Homo sapiens] IFNAR1 deficiency completely abolishes the reduction of sterol biosynthetic activity of macrophages during viral infections, thereby linking the regulation of lipid metabolism pathway with interferon anti-viral defence responses. (Demonstrated in murine model)

PMID 21695243

[Homo sapiens] IFNAR1 is phosphorylated by p38 MAP kinase in response to pathogen-recognition receptor stimulation. This phosphorylation promotes IFNAR1 ubiquitination and accelerates the proteolytic turnover of the receptor, which leads to attenuation of type I IFN signalling.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000142166:
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:91485238-91507441

Strand

Forward strand

Band

C3.3

Transcripts

ENSMUST00000023689	ENSMUSP00000023689
ENSMUST00000117748	ENSMUSP00000112670
ENSMUST00000123196	ENSMUSP00000119160
ENSMUST00000145008
ENSMUST00000129878	ENSMUSP00000120945

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004904	interferon receptor activity
GO:0005515	protein binding

Biological Process

GO:0019221	cytokine-mediated signaling pathway
GO:0032729	positive regulation of interferon-gamma production
GO:0042110	T cell activation
GO:0045087	innate immune response (InnateDB)
GO:0045351	type I interferon biosynthetic process
GO:0050718	positive regulation of interleukin-1 beta secretion
GO:0051607	defense response to virus